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Article
Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a clonal myeloproliferative disorder of early childhood. In all, 21 patients with JMML who received donor leukocyte infusion (DLI) after allogeneic hematopoietic stem...
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Article
Correlation of CD33 with poorer prognosis in childhood ALL implicates a potential of anti-CD33 frontline therapy
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Article
Transfer of genomics information to flow cytometry: expression of CD27 and CD44 discriminates subtypes of acute lymphoblastic leukemia
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Article
Allogeneic haematopoietic stem cell transplantation in children with acute lymphoblastic leukaemia: the BFM/IBFM/EBMT concepts
Children with high risk or relapsed acute lymphoblastic leukaemia (ALL) can benefit from allogeneic haematopoietic stem cell transplantation (SCT). To reduce transplantation-associated complications, the BFM s...
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Article
Stem cell transplantation for aplastic anemia and myelodysplastic syndrome
Stem cell transplantation (SCT) from a histocompatible sibling is treatment of choice for severe aplastic anemia. Survival rates have been reported to be as high as 90% for children. Immunosuppressive therapy ...
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Article
The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML)
The International Prognostic Scoring System (IPSS) for myelodysplastic syndrome (MDS) is based upon weighted data on bone marrow (BM) blast percentage, cytopenia, and cytogenetics, separating patients into fou...
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Article
Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry
The clinical significance of WT1 gene expression at diagnosis and during therapy of AML has not yet been resolved. We analysed WT1 expression at presentation in an unselected group of 47 childhood AML patients...
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Article
Acute lymphoblastic leukemia incidence during socioeconomic transition: selective increase in children from 1 to 4 years
Pre-school acute lymphoblastic leukemia (ALL) peak is consistent in developed but not in develo** countries and its magnitude apparently correlates with the socioeconomic status. A population-based study des...
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Chapter and Conference Paper
Mineral Resource Base of the Czech Republic for the XXI Century and its Management
Limited mineral fuel sources as coal deposits will be exhausted in a few decades. Czech Republic depends on import of crude oil, earth gas, metallic raw materials and raw materials for the production of fertil...
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Article
Treatment response and residual-disease monitoring in initial and relapsed TEL-AML1 positive childhood ALL
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Article
Statement of current majority practices in graft-versus-host disease prophylaxis and treatment in children
Great variations exist in the prophylaxis and treatment of GVHD in children undergoing allogeneic stem cell transplantation (SCT). The EBMT Working Party Paediatric Diseases (EBMT-WP PD) and the International ...
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Article
Detailed monitoring of hematopoietic chimerism in a child treated by adoptive immunotherapy for high risk of relapse after BMT for acute myeloid leukemia
We report a case of a 13-year-old boy who was transplanted for relapse of acute myeloid leukemia (AML). A detailed study of hematopoietic chimerism was performed using polymerase chain reaction (PCR) of variab...
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Article
Significantly lower relapse rate for TEL/AML1-positive ALL
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Article
Use of a skin explant model for predicting GVHD in HLA-matched bone marrow transplants – effect of GVHD prophylaxis
Over the last decade we have successfully evaluated the use of a human skin explant assay for predicting acute GVHD in HLA-matched sibling transplants. In the present study, we modified GVHD prophylaxis on an ...
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Article
Are we ready to curtail testing TEL/AML1 fusion?
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Article
Diamond-Biackfan Anaemia Registry in The Czech Republic
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Article
Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7
We reviewed the clinical features, treatment, and outcome of 100 children with myelodysplastic syndrome (MDS), juvenile myelomonocytic leukemia (JMML), and acute myeloid leukemia (AML) associated with complete...
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Article
TEL/AML1 positivity in childhood ALL: average or better prognosis?
The presence of TEL/AML1 fusion gene in childhood acute lymphoblastic leukaemia (ALL) defines a subgroup of patients with better than average outcome. However, the prognostic significance of this aberration ha...
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Article
Simple competitive two-step RT-PCR assay to monitor minimal residual disease in CML patients after bone marrow transplantation
Quantitative reverse transcription-polymerase chain reaction (Q-RT-PCR) assessing the amount of transcripts of the BCR/ABL gene, the molecular marker of chronic myeloid leukemia (CML), is the only method sensi...
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Article
Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity
The antigen KOR-SA3544 is physiologically expressed exclusively on granulocytes. Aberrant expression of KOR-SA3544 has been invariably found in BCR/ABL-positive acute lymphoblastic leukemia (ALL) and in some B...