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Article
Open AccessRegulation of intestinal stem cell fate specification
The remarkable ability of rapid self-renewal makes the intestinal epithelium an ideal model for the study of adult stem cells. The intestinal epithelium is organized into villus and crypt, and a group of intes...
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Article
The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells
Lgr5+ stem cells are crucial to gut epithelium homeostasis, and therapies targeting these cells hold promise for treatment of gastrointestinal diseases. Here we report that the non-muscle-myosin-II (NMII) heav...
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Article
Brightness temperature model of sea foam layer at L-band
Permittivity of a sea foam layer is very important in investigating ocean brightness temperature model. At microwave frequency, the Rayleigh method is developed to estimate the effective permittivity of the se...
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Article
Open AccessDapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation
Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation. However, how the com...
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Reference Work Entry In depth
Forward and Inverse Parameter Estimation for Metabolic Models
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Article
Analysis of cost functions for retrieving sea surface salinity
Two kinds of Bayesian-based cost functions (i.e., the unconstrained cost function and parameter-constrained cost function) are investigated for retrieving the sea surface salinity (SSS). In low SSS regions, we ha...
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Chapter
Mathematical Models of Dopamine Metabolism in Parkinson’s Disease
As discussed in Chap. 1 and elsewhere in this volume, a feature of Parkinson’s disease (PD) is a reduction in dopamine concentration in the striatum, caused by progressive loss of dopamine neurons in the subst...
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Chapter
Mathematical Models in Schizophrenia
Schizophrenia is a severe and complex mental disorder that causes an enormous societal and financial burden. Our current understanding of schizophrenia is very fragmented, and the disease is still regarded as ...
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Article
Open AccessThe internal state of medium spiny neurons varies in response to different input signals
Parkinson's disease, schizophrenia, Huntington's chorea and drug addiction are manifestations of malfunctioning neurons within the striatum region at the base of the human forebrain. A key component of these n...
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Article
Improved Image Based Visual Servoing with Parallel Robot
The position regulation problem of an eye-in-hand type of parallel robot based pointing systems (PRBPS) is considered in this paper. A fuzzy logic system is first designed to compensate for the uncertainties o...
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Article
Open AccessHarnessing the wealth of Chinese scientific literature: schistosomiasis research and control in China
The economy of China continues to boom and so have its biomedical research and related publishing activities. Several so-called neglected tropical diseases that are most common in the develo** world are stil...
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Article
A Novel Pose Estimation Algorithm Based on Points to Regions Correspondence
A novel pose estimation algorithm is put forward in this paper. Given the points on an object and the convex regions in which the correspondent image points lie, the concrete values of position and orientation (
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Article
Trajectory Tracking with Parallel Robots Using Low Chattering, Fuzzy Sliding Mode Controller
This paper proposes a trajectory tracking scheme which belongs to the sliding mode control (SMC) for the 4-degree-of-freedom (DOF) parallel robots. Two fuzzy logic systems (FLS) are first put forward to replac...
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Article
Autosomal Similarity Revealed by Eukaryotic Genomic Comparison
To describe eukaryotic autosomes quantitatively and determine differences between them in terms of amino acid sequences of genes, functional classification of proteins, and complete DNA sequences, we applied t...
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Article
Phylogeny of SARS-CoV as inferred from complete genome comparison
SARS-CoV, as the pathogeny of severe acute respiratory syndrome (SARS), is a mystery that the origin of the virus is still unknown even a few isolates of the virus were completely sequenced. To explore the gen...
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Article
The growth of Si1−x−yGexCy alloys with high carbon content by ultra-high vacuum chemical vapor deposition