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Article
Synthetic living materials in cancer biology
Living materials, which are made either of or by living cells, or are synthetic materials with programmable elements catered to cells, are environmentally responsive and can self-repair, allowing controlled an...
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Article
Open AccessiCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays
While microscopy-based cellular assays, including microfluidics, have significantly advanced over the last several decades, there has not been concurrent development of widely-accessible techniques to analyze ...
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Article
Open AccessIntegration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance
Resistance to ionizing radiation, a first-line therapy for many cancers, is a major clinical challenge. Personalized prediction of tumor radiosensitivity is not currently implemented clinically due to insuffic...
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Protocol
Systems Biology Approaches to Enzyme Kinetics
Intracellular drug metabolism involves transport, bioactivation, conjugation, and other biochemical steps. The dynamics of these steps are each dependent on a number of other cellular factors that can ultimate...
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Article
Open AccessAuthor Correction: Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
In the original version of this Article, an incorrect DOI number was provided in the Code Availability statement regarding the deposition of the computational model. The correct DOI is 10.5281/zenodo.1413539. ...
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Article
Open AccessDynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
The initiation of heterogeneity within a population of phenotypically identical progenitors is a critical event for the onset of morphogenesis and differentiation patterning. Gap junction communication within ...
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Article
Perspective: The Fundamental Value of Engineering Pedagogy for Realizing Personalized Medicine
Fundamental benefits suggest that biomedical engineering and medicine should form a more convergent alliance, especially for the training of tomorrow’s physicians and biomedical engineers. Herein, we review th...
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Article
Open AccessSpatially-resolved intracellular sensing of hydrogen peroxide in living cells
Understanding intracellular redox chemistry requires new tools for the site-specific visualization of intracellular oxidation. We have developed a spatially-resolved intracellular sensor of hydrogen peroxide, ...
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Article
Open AccessTrans-spliced Cas9 allows cleavage of HBB and CCR5 genes in human cells using compact expression cassettes
CRISPR/Cas9 systems have been used in a wide variety of biological studies; however, the large size of CRISPR/Cas9 presents challenges in packaging it within adeno-associated viruses (AAVs) for clinical applic...
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Protocol
Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
Intracellular drug metabolism involves transport, bioactivation, conjugation, and other biochemical steps. The dynamics of these steps are each dependent on a number of other cellular factors that can ultimate...
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Article
Conditioned Media Downregulates Nuclear Expression of Nrf2
Nuclear factor erythroid 2-related factor-2 (Nrf2) is a redox-sensitive transcription factor that activates several antioxidant and cytoprotective genes in response to oxidative stress. The role of Nrf2 activa...
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Reference Work Entry At a glance
Ligand
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Reference Work Entry At a glance
Agonist
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Reference Work Entry At a glance
Biological Network Model
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Reference Work Entry At a glance
Small Interfering RNA
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Reference Work Entry At a glance
Redox Enzymes
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Reference Work Entry At a glance
Redox Network
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Reference Work Entry At a glance
Reactive Oxygen Species (ROS)
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Reference Work Entry At a glance
Antagonist
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Reference Work Entry At a glance
Short Hairpin RNA
