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Article
Open AccessMetformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release
Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is the only drug demonstrated to reduce cardiovascular complicati...
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Article
Large-scale in vitro expansion of human regulatory T cells with potent xenoantigen-specific suppression
Xenotransplantation is a potential solution to the organ donor shortage. Immunosuppression is required for successful application of xenotransplantation but may lead to infection and cancer. Thus, strategies f...
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Article
A secure and efficient mutual authentication scheme for session initiation protocol
The Session Initiation Protocol (SIP) as the core signaling protocol for multimedia services is receiving much attention. Authentication is becoming increasingly crucial issue when a user asks to use SIP servi...
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Article
WT1 Expression in Circulating RNA as a Minimal Residual Disease Marker for AML Patients After Stem-Cell Transplantation
Circulating RNA in plasma (CRNA) refers to soluble tumor-derived ribonucleic acids (RNA). The Wilms tumor 1 (WT1) gene appears to be a highly promising marker for minimal residual disease (MRD) detection in acute...
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Article
High-fat diet combined with low-dose streptozotocin injections induces metabolic syndrome in Macaca mulatta
Metabolic syndrome (MetS) is associated with abdominal obesity, hyperlipidemia, insulin resistance, and type 2 diabetes mellitus, and increases the risk of cardiovascular disease. Given the complex multifacto...
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Article
Robust and Efficient Biometrics Based Password Authentication Scheme for Telecare Medicine Information Systems Using Extended Chaotic Maps
The Telecare Medicine Information Systems (TMISs) provide an efficient communicating platform supporting the patients access health-care delivery services via internet or mobile networks. Authentication become...
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Article
Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus (DM), which is a major public health problem in the world. To reveal the metabolic changes associated with DN, we analyzed the serum, ur...
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Article
Open AccessAn Enhanced Biometric-Based Authentication Scheme for Telecare Medicine Information Systems Using Elliptic Curve Cryptosystem
The telecare medical information systems (TMISs) enable patients to conveniently enjoy telecare services at home. The protection of patient’s privacy is a key issue due to the openness of communication environ...
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Article
Assessment of early renal damage in diabetic rhesus monkeys
The objectives of the study were to improve the model system of diabetic nephropathy in nonhuman primates and assess the early renal damage. Diabetes was induced in monkeys by streptozotocin, and the animals ...
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Article
Open AccessInvolvement of inflammation-related miR-155 and miR-146a in diabetic nephropathy: implications for glomerular endothelial injury
MicroRNAs have been demonstrated to play an important role in the pathogenesis of diabetic nephropathy (DN). In this study, we investigated both the repertoire of miRNAs in the kidneys of patients with DN and ...
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Article
Production and characterization of human soluble CD83 fused with the fragment crystallizable region of human IgG1 in Pichia pastoris
The cell surface protein CD83 belongs to the immunoglobulin superfamily and is highly expressed on mature dendritic cells. The soluble form of CD83, sCD83, is a potential immune suppressor. In a previous study...
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Article
Effect of Hypoxia-inducible Factor-1α Silencing on the Sensitivity of Human Brain Glioma Cells to Doxorubicin and Etoposide
Multidrug resistance (MDR) is a significant problem underlying the poor prognosis associated with gliomas. Hypoxia-inducible factor-1α (HIF-1α) is thought to induce the genes expression involved in MDR. To eva...
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Article
High-level expression of a functional humanized single-chain variable fragment antibody against CD25 in Pichia pastoris
CD25 is a marker molecule expressed on many T and B cell neoplasms and on activated T cells that mediate organ transplant rejection and many autoimmune diseases. Single-chain variable fragments (scFvs) have ma...
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Article
Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells
Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Danshen, a widely used Chinese herbal medicine. It has antioxidant properties, cytotoxic activities against multiple human cancer cells, ind...
