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Article
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that activates innate i...
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Article
Open AccessDigital coding of mechanical stress in a dynamic covalent shape memory polymer network
Controlling stresses in materials presents many unusual opportunities for their engineering applications. The potential for current approaches is severely limited by the intrinsic tie between the stress and th...
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Article
Open AccessArchitecture of the native major royal jelly protein 1 oligomer
Honeybee caste development is nutritionally regulated by royal jelly (RJ). Major royal jelly protein 1 (MRJP1), the most abundant glycoprotein among soluble royal jelly proteins, plays pivotal roles in honeybe...
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Article
Open AccessInfluences of anthropogenic land use on microbial community structure and functional potentials of stream benthic biofilms
Stream ecosystems are the primary receivers of nutrient and organic carbon exported from terrestrial ecosystems and are profoundly influenced by the land use of the surrounding landscape. The aquatic impacts o...
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Article
Open AccessA clinical investigation treating different types of fibroids identified by MRI-T2WI imaging with ultrasound guided high intensity focused ultrasound
Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This ...
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Article
Open AccessAstragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy
Aberrant endoplasmic reticulum (ER) stress and autophagy are associated with diabetic nephropathy. Here we investigated the effect of astragaloside IV (AS-IV) on the progression of diabetic nephropathy (DN) an...
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Article
Open AccessA Modified Preserved Nasal and Lacrimal Flap Technique in Endoscopic Dacryocystorhinostomy
Here we describe a modified preserved nasal and lacrimal mucosal flap technique in endonasal endoscopic dacryocystorhinostomy (EES-DCR) for patients with epiphora secondary to primary acquired nasolacrimal duc...
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Article
Open AccessA new method for identifying the cut ends in canalicular laceration
To locate the proximal and distal cut ends of the canaliculus following trauma is the most difficult part of canalicular repair, especially in patients with complex acute canalicular lacerations and late prese...
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Article
Open AccessA comparison of zircon U-Pb age results of the Red Clay sequence on the central Chinese Loess Plateau
Single grain zircon U-Pb geochronology has demonstrated great potentials in extracting tectonic and atmospheric circulation signal carried by aeolian, fluvial, and fluviolacustrine sediments. A routine in this...
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Open AccessErratum: An ultra-high density linkage map and QTL map** for sex and growth-related traits of common carp (Cyprinus carpio)
Scientific Reports 6: Article number: 26693; published online: 26 May 2016; updated: 22 July 2016 In the original version of this Article, Affiliation 3 was omitted for Wenzhu Peng. The correct affiliations ar...
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Open AccessThe ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1
Hepatitis E virus (HEV) genotype 1 infection is common and can emerge as outbreaks in develo** areas, thus posing a threat to public health. However, due to the absence of feasible animal models, the mechani...
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Article
Open AccessAn ultra-high density linkage map and QTL map** for sex and growth-related traits of common carp (Cyprinus carpio)
High density genetic linkage maps are essential for QTL fine map**, comparative genomics and high quality genome sequence assembly. In this study, we constructed a high-density and high-resolution genetic li...
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Article
Open AccessCorrection: Corrigendum: Loess Plateau storage of Northeastern Tibetan Plateau-derived Yellow River sediment
Nature Communications 6: Article number: 8511 (2015); Published: 9 October 2015; Updated: 18 February 2016. The original version of this Article contained errors in the Supplementary Information files: Zircon ...
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Article
Stereomeric effects of bisPC71BM on polymer solar cell performance
Two stereomers of bisadduct analogues of [6, 6]-phenyl-C71-butyric acid methyl ester (bisPC71BM) were synthesized and their geometrical structures with cis- or trans-configuration were identified by X-ray crystal...
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Article
Theoretical insight into the stereometric effect of bisPC71BM on polymer cell performance
It has been experimentally demonstrated that the stereometric packings of two new bisPC71BM isomers have an important impact on the power conversion efficiency of organic solar cells. Here, a theoretical investig...
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Article
Open AccessCorrelated compositional and mineralogical investigations at the Chang′e-3 landing site
The chemical compositions of relatively young mare lava flows have implications for the late volcanism on the Moon. Here we report the composition of soil along the rim of a 450-m diameter fresh crater at the ...
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Open AccessControllable Preparation of Ultrathin Sandwich-Like Membrane with Porous Organic Framework and Graphene Oxide for Molecular Filtration
Porous organic frameworks (POFs) based membranes have potential applications in molecular filtration, despite the lack of a corresponding study. This study reports an interesting strategy to get processable PO...
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Article
Open AccessLoess Plateau storage of Northeastern Tibetan Plateau-derived Yellow River sediment
Marine accumulations of terrigenous sediment are widely assumed to accurately record climatic- and tectonic-controlled mountain denudation and play an important role in understanding late Cenozoic mountain upl...
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Article
Open AccessHypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells
There is growing evidence that microRNAs play important roles in cellular responses to hypoxia and in pulmonary hypertensive vascular remodeling, but the exact molecular mechanisms involved are not fully eluci...
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Article
Resonant Raman spectroscopy of twisted multilayer graphene
Graphene and other two-dimensional crystals can be combined to form various hybrids and heterostructures, creating materials on demand with properties determined by the interlayer interaction. This is the case...