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Open AccessNanoparticle-based multivalent human antibodies offer potent and broad neutralization against Omicron sublineages
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Article
Open AccessIntranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and “anatomical escape” characteristics threaten the effectiveness of current coronavirus disease 2019 (COVID-19) vaccines...
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Prophylactic Hepatitis E Vaccine
The hepatitis E has been increasingly recognized as an underestimated global disease burden in recent years. Subpopulations with more serious infection associated damage or death include pregnant women, patien...
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The Risk of Transfusion-Transmitted Hepatitis E Virus: Evidence from Seroprevalence Screening of Blood Donations
Throughout the world, there has been growing concern over the risk of hepatitis E virus (HEV) transmission via blood transfusion. The present study screened blood donor samples for anti-HEV immunoglobulin M (I...
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Open AccessThe ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1
Hepatitis E virus (HEV) genotype 1 infection is common and can emerge as outbreaks in develo** areas, thus posing a threat to public health. However, due to the absence of feasible animal models, the mechani...
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Article
Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78
P239, a truncated construct of the hepatitis E virus (HEV) ORF2 protein, has been proven able to bind with a chaperone, Grp78, in both an in vitro co-immune precipitation test and an in vivo cell model. We pre...
