153 Result(s)

Article

Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response

Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...

Miao-Zhen Qiu, Chaoye Wang, Zhiying Wu, Qi Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study

Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. A prospectiv...

Junqi Wu, Chongwu Li, Peigen Gao… in Signal Transduction and Targeted Therapy (2023)

Article

ICAM2 initiates trans-blood-CSF barrier migration and stemness properties in leptomeningeal metastasis of triple-negative breast cancer

Leptomeningeal metastasis (LM) occurs when tumor cells spread to the leptomeningeal space surrounding the brain and the spinal cord, thereby causing poor clinical outcomes. The triple-negative breast cancer (T...

Jhih-Kai Pan, Wen-Der Lin, Yao-Lung Kuo, Yu-Chia Chen, Zhu-Jun Loh… in Oncogene (2023)

Article

Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression

Atrial fibrillation (AF) is a frequent arrhythmia associated with cardiovascular morbidity and mortality. Neutrophil extracellular traps (NETs) are DNA fragments with cytoplasm proteins released from neutrophi...

Li He, Ruiqi Liu, Honghua Yue, **aoxin Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different TRP channel proteins, which can be divided into seven subfam...

Miao Zhang, Yueming Ma, **anglu Ye, Ning Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Efficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial

This phase I/II trial characterized the tolerability, safety, and antitumor activities of unecritinib, a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1, ALK, and c-MET, in ...

Shun Lu, Hongming Pan, Lin Wu, Yu Yao… in Signal Transduction and Targeted Therapy (2023)

Article

Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12

Cancer relapse and metastasis are major obstacles for effective treatment. One important mechanism to eliminate cancer cells is to induce apoptosis. Activation of executioner caspases is the key step in apopto...

Yuxing Wang, Ru Wang, **aohe Liu, Menghao Liu, Lili Sun, … in Oncogenesis (2023)

Article

Exosomal circSPIRE1 mediates glycosylation of E-cadherin to suppress metastasis of renal cell carcinoma

Metastasis is the main cause of mortality in renal cell carcinoma (RCC). Circular RNAs (circRNAs) involvement in RCC metastasis has been described, although the underlying mechanisms remain unknown. We evaluat...

Guannan Shu, Xuanxuan Lu, Yihui Pan, Junjie Cen, Kangbo Huang, Mi Zhou, Jun Lu… in Oncogene (2023)

Article

Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood

Ran Li, **g Zou, Dongling Pei, Ting Pan… in Signal Transduction and Targeted Therapy (2023)

Article

SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...

Pan Pan, Weiwei Ge, Zhiwei Lei, Wei luo… in Signal Transduction and Targeted Therapy (2023)

Article

Integrative multi-omics and drug–response characterization of patient-derived prostate cancer primary cells

Prostate cancer (PCa) is the second most prevalent malignancy in males across the world. A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment f...

Ziruoyu Wang, Yanan Li, Wensi Zhao, Shuai Jiang… in Signal Transduction and Targeted Therapy (2023)

Article

LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway

LZTFL1 is a tumor suppressor located in chromosomal region 3p21.3 that is deleted frequently and early in various cancer types including the kidney cancer. However, its role in kidney tumorigenesis remains unk...

Jun Lu, Liang-min Fu, Yun Cao, Yong Fang, Jia-zheng Cao, Yi-hui Pan… in Oncogene (2023)

Article

Correction: Epigenetic targeting of neuropilin-1 prevents bypass signaling in drug-resistant breast cancer

Ammara Abdullah, Saeed Salehin Akhand, Juan Sebastian Paez Paez, Wells Brown… in Oncogene (2023)

Article

Spatiotemporal regulation of cholangiocarcinoma growth and dissemination by peritumoral myofibroblasts in a Vcam1-dependent manner

Intrahepatic cholangiocarcinoma (iCCA) is characterized by its highly desmoplastic stroma. Myofibroblasts (MFs) are present both within the tumor mass (intratumoral MFs, iMFs) and at the tumor border (peritumo...

Cheng Tian, Liyuan Li, Qingfei Pan, Beisi Xu, Yizhen Li, Li Fan, Anthony Brown… in Oncogene (2023)

Article

The loss of epigenetic information: not only consequences but a cause of mammalian aging

Chen Pan, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2023)

Article

Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2

Constitutive activation of RAS-RAF-MEK-ERK signaling pathway (MAPK pathway) frequently occurs in many cancers harboring RAS or RAF oncogenic mutations. Because of the paradoxical activation induced by a single...

Penglei Wang, Xuechao Jia, Bingbing Lu… in Signal Transduction and Targeted Therapy (2023)

Article

CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability

Lymph node (LN) metastasis is one of the most malignant clinical features in patients with cervical cancer (CCa). Understanding the mechanism of lymph node metastasis will provide treatment strategies for pati...

Chunyu Zhang, Hongye Jiang, Li Yuan, Yuandong Liao, Pan Liu, Qiqiao Du… in Oncogene (2023)

Article

Bifunctional small molecules targeting PD-L1/CXCL12 as dual immunotherapy for cancer treatment

Binbin Cheng, Wei Wang, Ting Liu, Hao Cao… in Signal Transduction and Targeted Therapy (2023)

Article

TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN

We report herein that TSPAN32 is a key node factor for Philadelphia (Ph⁺) leukemia pathogenesis. We found that TSPAN32 expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment in...

Qiang Qiu, Yuanyuan Sun, Linyu Yang… in Signal Transduction and Targeted Therapy (2023)

Article

A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype

Qiong Zhao, Hui Chang, **g Zheng, ** Li… in Signal Transduction and Targeted Therapy (2023)