Dear Editor,

Inflammatory bowel disease (IBD), a complex syndrome characterized by chronic inflammation of the gastrointestinal tract, is considered a global health problem, especially prevalent in western developed countries and with accelerating incidence in the develo** world over the last decade.

Data availability

All data and materials are presented in the main manuscript or supplementary materials and are available on request. RNA and 16 s rDNA sequencing data were deposited into Sequence Read Archive (SRA) with the Bio-project ID of PRJNA833575 and PRJNA855381.

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Acknowledgements

This work was supported by the National Key Research and Development Program of China (2020YFA0113003, 2018YFC1004803), the Natural Science Foundation of China (31630083, 82071063), CAMS Innovation Fund for Medical Sciences (2022-I2M-1-012), and the Fundamental Research Funds for the Central Universities. We are grateful to Dr. Min-**n Guan (Zhejiang University) for valuable suggestions and support, Dr. Yanchun Ji (The Children’s Hospital, Zhejiang University School of Medicine), and Dr. Feilong Meng (The Children’s Hospital, Zhejiang University School of Medicine), and Dr. Juan Du (The First Affiliated Hospital, Zhejiang University School of Medicine) for technical support.

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Author notes

  1. These authors contributed equally: Qiong Zhao, Hui Chang

Authors and Affiliations

  1. Department of Genetics, and Department of Genetic and Metabolic Disease, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China

    Qiong Zhao, Hui Chang, **g Zheng & Ye Chen

  2. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Bei**g, 100005, China

    Di Li & Robert Chunhua Zhao

  3. College of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, Hangzhou, 310052, China

    Jian-Zhong Shao

  4. Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders, Institute of Genetics, Zhejiang University, Hangzhou, 310052, China

    Qiong Zhao, Hui Chang, **g Zheng & Ye Chen

  5. Key Laboratory for Food Microbial Technology of Zhejiang Province, Zhejiang Gongshang University, Hangzhou, China

    ** Li

  6. Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China

    Lidan Ye

  7. Zhejiang Provincial Key Laboratory of Cell‐Based Drug and Applied Technology Development, Institute for Cell‐Based Drug Development of Zhejiang Province, Hangzhou, China

    Ruolang Pan

Authors
  1. Qiong Zhao
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  2. Hui Chang
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  4. ** Li
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  7. Di Li
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  8. Jian-Zhong Shao
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  9. Robert Chunhua Zhao
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  10. Ye Chen
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Contributions

Y.C, R.C. Zhao, and JZ.S conceptualized the study. Q.Z, H.C, J.Z, P.L, LD.Y, RL.P, and D.L performed the experiments and analyzed the data. Q.Z, JZ.S, R.C. Zhao, and Y.C interpreted the data and wrote the manuscript. All authors have read and approved the article.

Corresponding authors

Correspondence to Jian-Zhong Shao, Robert Chunhua Zhao or Ye Chen.

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Competing interests

The authors declare no competing interests.

Ethics declarations

The study protocol was approved by the Institutional Review Board of Zhejiang University and all animal procedures were performed according to protocols approved by the Institutional Animal Care and Use Committee at Zhejiang University (application ID: 18021).

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Zhao, Q., Chang, H., Zheng, J. et al. A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype. Sig Transduct Target Ther 8, 86 (2023). https://doi.org/10.1038/s41392-023-01318-6

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  • DOI: https://doi.org/10.1038/s41392-023-01318-6

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