51 Result(s)
within
Huan-**n Sun
Life Sciences
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Article
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia
Severe cases of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with elevated blood glucose levels and metabolic complications. However, the molecular mechanisms for ...
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Open AccessGenome-Wide Identification and Expression Analysis of AP2/EREBP Transcription Factors in Litchi (Litchi chinensis Sonn.)
APETALA2/ethylene response element binding proteins (AP2/EREBP) are a vital type of TF involved in plant organ development and embryogenesis. In this study we identified 202 Litchi AP2/EREBP TFs from the litch...
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Open AccessTransmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer
Upregulation of transmembrane protein 97 (TMEM97) has been associated with progression and poor outcome in multiple human cancers, including breast cancer. Recent studies suggest that TMEM97 may be involved in...
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Open AccessTrans-ethnic genome-wide association study of severe COVID-19
COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symp...
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Open AccessThe Cardamine enshiensis genome reveals whole genome duplication and insight into selenium hyperaccumulation and tolerance
Cardamine enshiensis is a well-known selenium (Se)-hyperaccumulating plant. Se is an essential trace element associated with many health benefits. Despite its critical importance, genomic information of this spec...
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Open AccessG-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence
Aging is one of the most prominent risk factors for heart failure. Myeloid-derived suppressor cells (MDSCs) accumulate in aged tissue and have been confirmed to be associated with various aging-related disease...
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Ziziphus jujuba Mill., a plant used as medicinal food: a review of its phytochemistry, pharmacology, quality control and future research
Jujubae Fructus (ZJF) [called Dazao (大枣) in Chinese], the fruit of Ziziphus jujuba Mill. (ZJ), is utilized as a food and traditional medicine in China. In TCM use, ZJF is traditionally used to treat and nourish t...
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Open AccessThe dissection of R genes and locus Pc5.1 in Phytophthora capsici infection provides a novel view of disease resistance in peppers
Phytophthora capsici root rot (PRR) is a disastrous disease in peppers (Capsicum spp.) caused by soilborne oomycete with typical symptoms of necrosis and constriction at the basal stem and consequent plant wiltin...
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Open AccessGalectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease
Alzheimer’s disease (AD) is the most common cause of dementia and is characterized by the deposition of extracellular aggregates of amyloid-β (Aβ), the formation of intraneuronal tau neurofibrillary tangles an...
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Open AccessCotton pan-genome retrieves the lost sequences and genes during domestication and selection
Millennia of directional human selection has reshaped the genomic architecture of cultivated cotton relative to wild counterparts, but we have limited understanding of the selective retention and fractionation...
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QTL map** of the genetic basis of stem diameter in soybean
QTL map** of stem diameter was carried out in three RIL populations using a high-density genetic map, and candidate genes related to stem diameter were predicted.
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Coinfection with influenza A virus enhances SARS-CoV-2 infectivity
The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) ...
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Open AccessHomotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome
Cytosolic inflammasomes are supramolecular complexes that are formed in response to intracellular pathogens and danger signals. However, as to date, the detailed description of a homotypic caspase recruitment ...
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Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based assay
Pseudotyped viruses are useful virological tools because of their safety and versatility. On the basis of a vesicular stomatitis virus (VSV) pseudotyped virus production system, we developed a pseudotyped viru...
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Open AccessMiR-200b in heme oxygenase-1-modified bone marrow mesenchymal stem cell-derived exosomes alleviates inflammatory injury of intestinal epithelial cells by targeting high mobility group box 3
Heme Oxygen-1 (HO-1)-modified bone marrow mesenchymal stem cells (BMMSCs) are effective to protect and repair transplanted small bowel and intestinal epithelial cells (IECs); however, the mechanism and the rol...
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Open AccessRETRACTED ARTICLE: Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts
Donation after circulatory death (DCD) liver grafts have a poor prognosis after transplantation. We investigated whether the outcome of DCD donor organs can be improved by heme oxygenase 1 (HO-1)-modified bone...
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Influence of the degree of donor bone marrow hyperplasia on patient clinical outcomes after allogeneic hematopoietic stem cell transplantation
This study evaluated the influence of the degree of donor bone marrow (BM) hyperplasia on patient clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twelve patients receive...
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Open AccessMap** and identification of CsUp, a gene encoding an Auxilin-like protein, as a putative candidate gene for the upward-pedicel mutation (up) in cucumber
Pedicel orientation can affect the female flower orientation and seed yield in cucumber.
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Open AccessSea cucumber genome provides insights into saponin biosynthesis and aestivation regulation
Echinoderms exhibit several fascinating evolutionary innovations that are rarely seen in the animal kingdom, but how these animals attained such features is not well understood. Here we report the sequencing a...
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The Hog1-like MAPK Mpk3 collaborates with Hog1 in response to heat shock and functions in sustaining the biological control potential of a fungal insect pathogen
The mitogen-activated protein kinase (MAPK) Mpk3/MpkC resembles the MAPK Hog1 but does not necessarily function in some filamentous fungi. Here, we compared functions of Mpk3 and Hog1 in Beauveria bassiana, a fil...
