49 Result(s)

Article

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate Cancer Prevention Trial

Compelling and long-standing data suggest that androgens play an important role in the development of both normal prostate epithelium and prostate cancer. Although testosterone administration can induce prosta...

Jeannette M. Schenk, Cathee Till, Ann W. Hsing… in Cancer Causes & Control (2016)

Article

Prospective study of human herpesvirus type 8 serostatus and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial

Human herpesvirus type 8 (HHV-8), a gamma herpesvirus associated with Kaposi’s sarcoma, has been proposed as a candidate risk factor for prostate cancer (PCa) because of its detection in benign and malignant p...

Siobhan Sutcliffe, Cathee Till, Frank J. Jenkins… in Cancer Causes & Control (2015)

Article

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new sus...

Ali Amin Al Olama, Zsofia Kote-Jarai, Sonja I Berndt, David V Conti… in Nature Genetics (2014)

Article

A genome-wide association study of prostate cancer in West African men

Age-adjusted mortality rates for prostate cancer are higher for African-American men compared with those of European ancestry. Recent data suggest that West African men also have elevated risk for prostate can...

Michael Blaise Cook, Zhaoming Wang, Edward D. Yeboah, Yao Tettey… in Human Genetics (2014)

Article

Prospective study of cytomegalovirus serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial

To investigate serologic evidence of infection by cytomegalovirus (CMV), a herpesvirus with known oncogenic potential that has been detected in malignant prostate tissue, in relation to prostate cancer (PCa) r...

Siobhan Sutcliffe, Cathee Till, Charlotte A. Gaydos… in Cancer Causes & Control (2012)

Article

Detectable clonal mosaicism and its relationship to aging and cancer

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such ...

Kevin B Jacobs, Meredith Yeager, Weiyin Zhou, Sholom Wacholder… in Nature Genetics (2012)

Article

Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies

Although many studies have linked obesity with increased risk of thyroid cancer, few have investigated the role of obesity-related lifestyle characteristics and medical conditions in the etiology of this disea...

Cari M. Kitahara, Elizabeth A. Platz, Laura E. Beane Freeman… in Cancer Causes & Control (2012)

Article

Improved imputation of common and uncommon SNPs with a new reference set

Zhaoming Wang, Kevin B Jacobs, Meredith Yeager, Amy Hutchinson… in Nature Genetics (2012)

Article

Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation

Several lines of evidence suggest that inflammation may play a role in the etiology of biliary tract cancers. To examine further the role of inflammation, we evaluated the associations between self-reported in...

Gabriella Andreotti, Enju Liu, Yu-Tang Gao, Mahboobeh Safaeian… in Cancer Causes & Control (2011)

Article

Dietary carbohydrate, glycemic index, glycemic load, and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort

To evaluate the associations between dietary carbohydrate, glycemic index (GI), glycemic load (GL), and incident prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) coh...

James M. Shikany, Andrew P. Flood, Cari M. Kitahara… in Cancer Causes & Control (2011)

Article

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Christopher Haiman and colleagues report a genome-wide association study for prostate cancer in African-American males drawn from 11 epidemiological studies of prostate cancer, with replication including indiv...

Christopher A Haiman, Gary K Chen, William J Blot, Sara S Strom… in Nature Genetics (2011)

Article

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Paul Brennan, Stephen Chanock and colleagues performed a genome-wide association study for renal carcinoma. They identified two genetic susceptibility loci.

Mark P Purdue, Mattias Johansson, Diana Zelenika, Jorge R Toro… in Nature Genetics (2011)

Article

Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies

Data on long-term intra-individual variability in high-sensitivity C-reactive protein (hsCRP) are needed to determine whether one measurement adequately reflects usual levels in prospective studies of on the e...

Elizabeth A. Platz, Siobhan Sutcliffe, Angelo M. De Marzo… in Cancer Causes & Control (2010)

Chapter

Androgens and Prostate Cancer

Prostate cancer is the most common nonskin cancer among American men and the third leading cause of cancer deaths. Research data over many years of study support the role of androgen in driving prostate cancer...

Douglas K. Price, Ann W. Hsing in Drug Management of Prostate Cancer (2010)

Article

Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China

We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based s...

Gabriella Andreotti, Idan Menashe, **bo Chen… in European Journal of Epidemiology (2009)

Chapter

Androgen-Metabolic Genes in Prostate Cancer Predisposition and Progression

Prostate cancer is the most common nonskin cancer and the second leading cause of cancer deaths among men in most Western countries, including the US and Australia. Despite its high morbidity and mortality, th...

Juergen K.V. Reichardt, Ann W. Hsing in Androgen Action in Prostate Cancer (2009)