36 Result(s)
within
Aiwen **e
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessElectrochemical oxidation induced intermolecular aromatic C-H imidation
The dehydrogenative aryl C-H/N-H cross-coupling is a powerful synthetic methodology to install nitrogen functionalities into aromatic compounds. Herein, we report an electrochemical oxidation induced intermole...
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Open AccessDirect electrochemical oxidation of alcohols with hydrogen evolution in continuous-flow reactor
Alcohol oxidation reactions are widely used for the preparation of aldehydes and ketones. The electrolysis of alcohols to carbonyl compounds have been underutilized owing to low efficiency. Herein, we report a...
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Open AccessElectrooxidative para-selective C–H/N–H cross-coupling with hydrogen evolution to synthesize triarylamine derivatives
Oxidative C–H/N–H cross-coupling is one of the most atom-economical methods for the construction of C–N bonds. However, traditional oxidative C–H/N–H cross-coupling either required the use of strong oxidants o...
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Article
Open AccessVisible light-induced direct α C–H functionalization of alcohols
Considering the synthetic value of introducing active alcoholic hydroxyl group, develo** C–H functionalization of alcohols is of significance. Herein, we present a photochemical method that under visible lig...
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Article
Open AccessOxidative [4+2] annulation of styrenes with alkynes under external-oxidant-free conditions
The sequenced Diels–Alder/oxidation reaction represents a powerful route for the construction of aromatic compounds in organic synthesis. The oxidative Diels–Alder reaction with H2 evolution would be a more ideal...
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Article
Open AccessCryo-EM structure of the polycystic kidney disease-like channel PKD2L1
PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels), is involved in the sour sensation and other pH-dependent processes. PKD2L1 is believed to be a nonselective cation channel that can ...
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Open AccessCobalt-catalyzed electrooxidative C-H/N-H [4+2] annulation with ethylene or ethyne
Ethylene and ethyne are among the simplest two-carbon building blocks. However, quite limited methods can be applied to incorporate ethylene or ethyne into fine chemicals. Here we demonstrate a cobalt-catalyze...
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Open AccessExternal oxidant-free electrooxidative [3 + 2] annulation between phenol and indole derivatives
Intermolecular [3 + 2] annulation is one of the most straightforward approaches to construct five membered heterocycles. However, it generally requires the use of functionalized substrates. An ideal reaction a...
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Article
Open Accessp32 heterozygosity protects against age- and diet-induced obesity by increasing energy expenditure
Obesity is increasing in prevalence and has become a global public health problem. The main cause of obesity is a perturbation in energy homeostasis, whereby energy intake exceeds energy expenditure. Although ...
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Open AccessUnravelling the hidden link of lithium halides and application in the synthesis of organocuprates
As a versatile metal, copper has demonstrated a wide application in acting as both organometallic reagent and catalyst. Organocuprates are among the most used organometallic reagents in the formation of new ca...
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Open AccessPhoto-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles
Direct cross-coupling between simple arenes and heterocyclic amines under mild conditions is undoubtedly important for C–N bonds construction. Selective C(sp2)-H amination is more valuable. Herein we show a selec...
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Open AccessMultimetallic catalysed radical oxidative C(sp3)–H/C(sp)–H cross-coupling between unactivated alkanes and terminal alkynes
Radical involved transformations are now considered as extremely important processes in modern organic synthetic chemistry. According to the demand by atom-economic and sustainable chemistry, direct C(sp3)–H func...
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Open AccessTuning the Reactivity of Radical through a Triplet Diradical Cu(II) Intermediate in Radical Oxidative Cross-Coupling
Highly selective radical/radical cross-coupling is paid more attention in bond formations. However, due to their intrinsic active properties, radical species are apt to achieve homo-coupling instead of cross-c...
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Article
Open AccessTopological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury
Data-driven discovery in complex neurological disorders has potential to extract meaningful syndromic knowledge from large, heterogeneous data sets to enhance potential for precision medicine. Here we describe...
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Article
Open AccessThe extent of inflammatory infiltration in primary cancer tissues is associated with lymphomagenesis in immunodeficient mice
Xenotransplantation of human cancers into immunodeficient mice is a very useful approach for studying human tumor biology. However, the occasional occurrence of lymphomagenesis in some mice can spoil the model...
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Open AccessA subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy
A preclinical trial identified 4 of 20 (20%) gastric cancer (GC) patient-derived xenografts responded to cetuximab. Genome-wide profiling and additional investigations revealed that high EGFR mRNA expression a...
