-
Article
Open AccessGSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we gene...
-
Article
Open AccessA life cycle and product type based estimator for quantifying the carbon stored in wood products
Timber harvesting and industrial wood processing laterally transfer the carbon stored in forest sectors to wood products creating a wood products carbon pool. The carbon stored in wood products is allocated to...
-
Article
Aggregation kinetics and morphological changes of PFR and establishment of triple-layer surface complexation model to explain ion difference
The anions in the phenol–formaldehyde resin colloid interact with the metal cations in the system to form aggregates with different fractal structures. In this study, Mg2+ and Na+ were studied. At low cationic co...
-
Article
Construction of a novel nth-order polynomial chaotic map and its application in the pseudorandom number generator
Chaotic maps with good chaotic performance have been extensively designed in cryptography recently. This paper gives an nth-order polynomial chaotic map by using topological conjugation with piecewise linear chao...
-
Article
The Integrated Analysis of Transcriptomics and Metabolomics Unveils the Therapeutical Effect of Asiatic Acid on Alcoholic Hepatitis in Rats
The present study was to investigate the therapeutical effects and mechanisms of Asiatic acid from Potentilla chinensis against alcoholic hepatitis. Rats were intragastrically fed with alcohol for 12 weeks to ind...
-
Article
Open AccessEGFR, HER2, and HER3 protein expression in paired primary tumor and lymph node metastasis of colorectal cancer
Due to the difficulty in sampling of metastatic tumors, patient selection is commonly based on results of primary tumor samples when metastatic samples are not available. However, due to tumor heterogeneity, m...
-
Article
Analytical Prediction of Three Dimensional Chatter Stability Considering Multiple Parameters in Milling
Chatter has been playing an important role in the stability and quality assurance of milling processes. To effectively predict the stability of milling processes, in this paper, we investigate multiple milling...
-
Article
Research on the slow orbit feedback of BEPCII using machine learning
Long-term orbit stability is a key performance indicator in synchrotron radiation facilities and colliders nowadays, in which the orbit correction and corresponding slow orbit feedback system are indispensable...
-
Article
Flexible Broadband Light Absorbers with a Superhydrophobic Surface Fabricated by Ultraviolet-assisted Nanoimprint Lithography
We present a simple approach to fabricate a kind of composite films with a superhydrophobic and broadband light absorbing surface by ultraviolet-assisted nanoimprinting over a gradiently deposited composite ma...
-
Article
Construction and application of new high-order polynomial chaotic maps
Generating pseudorandom numbers with good statistical performance based on chaotic maps has become a topic of interest in chaotic cryptography. Several high-order polynomial chaotic maps with special forms are...
-
Article
Open AccessExosomes for gene therapy effectively inhibit the endothelial-mesenchymal transition in mouse aortic endothelial cells
Heterotopic ossification (HO) can limit joint activity, causes ankylosis and impairs the function and rehabilitation of patients. Endothelial to mesenchymal transition (EndMT) plays an important role in the pa...
-
Article
Open AccessPSMC2 knockdown suppressed tumor progression of skin cutaneous melanoma
Skin cutaneous melanoma (SKCM) is the most lethal tumor among three of the major malignant cancers of the skin. The mechanism underlying the malignant biological behaviors of SKCM is not fully clear. Our study...
-
Article
Open AccessTargeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor
A zero-reflection-induced phase singularity is achieved through precisely controlling the resonance characteristics using two-dimensional nanomateria...
-
Article
Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance
The successful treatment of human cancers by immunotherapy has been made possible by breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD-1/PD-L1. However, the immunosuppress...
-
Chapter and Conference Paper
GES: An Efficient Evaluation Experts Selecting Strategy Based on Genetic Algorithm
In the evaluation of technology projects, multiple experts need to be selected to evaluate a group of projects each of which covers different technology fields. However, each expert has his own advantage field...
-
Article
Florfenicol induces renal toxicity in chicks by promoting oxidative stress and apoptosis
To explore the mechanism of renal toxicity induced by florfenicol (FFC), 120 chicks were randomly divided into 6 groups, 20 in each group. Except for the control group, different doses of FFC (0.15 g/L, 0.3 g/...
-
Article
The transfer line design for the HEPS project
The high energy photon source (HEPS), a 6-GeV synchrotron radiation facility with ultralow emittance, is under construction in China. Three transfer lines are designed for HEPS. One low-energy transfer line is...
-
Article
Bisphenol A in utero exposure induces ovary dysfunction in mice offspring and the ameliorating effects of Cuscuta chinensis flavonoids
To study the alleviating effects of flavonoids from Cuscuta chinensis (CCFs) on ovary injury in female offspring of pregnant mice exposed to BPA, five groups (n = 20) of pregnant mice were intragastrically admini...
-
Article
Open AccessCoexistence of valley polarization and Chern insulating states in MoS2 monolayers with n-p codo**
The electronic and topological properties of MoS2 monolayers with n-p codo** effect are investigated by using first-principles calculations. Two types of the doped Nb atoms play the roles of the p-type and n-ty...
-
Article
Alda-1, an Aldehyde Dehydrogenase 2 Agonist, Improves Cutaneous Wound Healing by Activating Epidermal Keratinocytes via Akt/GSK-3β/β-Catenin Pathway
The cutaneous wound healing process mainly comprises re-epithelialization, fibrosis, and neovascularization. Impaired wound healing is common but tricky in plastic surgery. Aldehyde dehydrogenase 2 (ALDH2), th...
