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Article
Open AccessA widely conserved protein Rof inhibits transcription termination factor Rho and promotes Salmonella virulence program
Transcription is crucial for the expression of genetic information and its efficient and accurate termination is required for all living organisms. Rho-dependent termination could rapidly terminate unwanted pr...
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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Article
Associations of slee** patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults
Studies have found a U-shaped relationship between sleep duration and chronic kidney disease (CKD) risk, but limited research evaluated the association of reallocating excessive sleep to other behavior with CK...
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Article
Recent advances in chemical protein synthesis: method developments and biological applications
The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes, the study of which necessitates advanced methods to produce proteins with precision and versatil...
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Open AccessTargeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Current anticancer therapies cannot eliminate all cancer cells, which hijack normal arginine methylation as a means to promote their maintenance via unknown mechanisms. Here we show that targeting protein argi...
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Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Open AccessSearch for new phenomena with top-quark pairs and large missing transverse momentum using 140 fb−1 of pp collision data at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A search is conducted for new phenomena in events with a top quark pair and large missing transverse momentum, where the top quark pair is reconstructed in final states with one isolated electron or muon and m...
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Article
Melatonin Enhanced Microglia M2 Polarization in Rat Model of Neuro-inflammation Via Regulating ER Stress/PPARδ/SIRT1 Signaling Axis
Neuro-inflammation involves distinct alterations of microglial phenotypes, containing nocuous pro-inflammatory M1-phenotype and neuroprotective anti-inflammatory M-phenotype. Currently, there is no effective t...
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Article
Open AccessDirect visualization of stacking-selective self-intercalation in epitaxial Nb1+xSe2 films
Two-dimensional (2D) van der Waals (vdW) materials offer rich tuning opportunities generated by different stacking configurations or by introducing intercalants into the vdW gaps. Current knowledge of the inte...
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Article
Open AccesscGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors
Type I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy,...
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Article
Quality of life in patients with nasopharyngeal carcinoma receiving IMRT vs IMPT: a multicenter prospective longitudinal study
Nasopharyngeal carcinoma (NPC) patients may experience symptom distress and depression during and after radiation therapy, which negatively impacts quality of life (QOL). We sought to identify trajectories of ...
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
Experimental study on electrode materials characteristics for dewatering and remediation of copper-contaminated sediment from Tai Lake based on vacuum electro-osmosis
The vacuum electro-osmosis method enables integrated treatment of heavy metal-contaminated sediments by simultaneously removing water and pollutants. This study focuses on the dredged sediments from Tai Lake a...
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Open AccessRobotic Versus Thoracoscopic Sub-lobar Resection for Octogenarians with Clinical Stage IA Non-small Cell Lung Cancer: A Propensity Score-Matched Real-World Study
Minimally invasive sub-lobectomy is sufficient in treating small early-stage non-small cell lung cancer (NSCLC). However, comparison of the feasibility and oncologic efficacy between robot-assisted thoracoscop...
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Open AccessNanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment
Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factor...
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Article
Open AccessDesign of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations
We introduce a computational approach for the design of target-specific peptides. Our method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta FlexPepDock for peptide sequence genera...
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Article
Synergistic Effect of Temperature Cycling and Atomic Oxygen on the Parallel Gap Resistance Welding Joint in GaAs Space Solar Panel
Spacecraft in near-Earth orbits endure a multifaceted space environment, predominantly influenced by orbital temperature cycling and atomic oxygen (AO). The operational reliability of solar panels, essential f...
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Article
Open AccessShape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating
Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by ...
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Article
Ground settlement caused by pipe-roof pre-construction method: Effect of the sequence of jacking pipe groups
Based on the Taiyuan Railway Station underpass tunnel project, the influence of construction process of closed pipe-roof pre-construction structures on the ground settlement was investigated. Numerical simulat...
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Observation and quantification of the pseudogap in unitary Fermi gases
The microscopic origin of high-temperature superconductivity in cuprates remains unknown. It is widely believed that substantial progress could be achieved by better understanding of the pseudogap phase, a nor...
