206 Result(s)
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Article
The nonpeptide AVE0991 attenuates myocardial hypertrophy as induced by angiotensin II through downregulation of transforming growth factor-β1/Smad2 expression
The nonpeptide AVE0991 is expected to be a putative new drug for cardiovascular diseases. However, the mechanisms for the cardioprotective actions of AVE0991 are still not fully understood. We planned to deter...
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Article
Tumor cell lysate-pulsed dendritic cells induce a T cell response against colon cancer in vitro and in vivo
To investigate whether tumor cell lysate-pulsed (TP) dendritic cells (DCs) induce cytotoxic T lymphocyte (CTL) activity against colon cancer in vitro and in vivo. Hematopoietic progenitor cells were magnetically ...
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Article
Antitumor effects of recombinant human Interleukin-6 on mouse bladder carcinoma through Fas-mediated apoptosis
An apoptosis-inducing therapy is gradually becoming a new strategy for cancer treatment. The aim of this study was to investigate the mechanism of growth-inhibitory effects of recombinant human interleukin-6 (...
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Article
The role of endoplasmic reticulum stress in the early stage of diabetic retinopathy
The aim of this study was to evaluate the role of endoplasmic reticulum (ER) stress in diabetic retinopathy (DR) using in vitro and in vivo models. For the in vivo studies, diabetes was induced in rats, and re...
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Article
Effect of early intervention with extract of Huannao Yicong Decoction (还脑益聪方) on the pathologic picture of hippocampus and neurocyte apoptosis in APP transgenic mice model of dementia
To observe the effect of early intervention using extract of Huannao Yicong Decoction (还脑益聪方, HYD) on the pathological picture of hippocampus, neurocyte apoptosis, and associated regulatory genes in β-amyloid ...
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Article
Association between AKT/mTOR signalling pathway and malignancy grade of human gliomas
The mammalian target of rapamycin (mTOR) signaling pathway has emerged as a major effector of cell growth and proliferation, and is an attractive target for cancer therapy. However, the association between mTO...
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Article
Interleukin-1 receptor antagonist reduced apoptosis and attenuated intestinal mucositis in a 5-fluorouracil chemotherapy model in mice
The aim of this study was to investigate the relationship between changes in IL-1β expression and intestinal apoptosis after chemotherapy. And we further determine whether interleukin-1 receptor antagonist (IL...
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Article
Primary breast lymphoma (PBL): A literature review
Primary breast lymphoma is a rare disease. It is mainly found in female patients, the right breast in more frequently involved. The majority of PBL are diagnosed by biopsy or postoperative pathological finding...
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Article
Expression of the Golgi phosphoprotein-3 gene in human gliomas: a pilot study
The oncogene Golgi phosphoprotein 3 (GOLPH3) has been found in several solid cancers, but its expression in glioma tumor tissues is unknown. Reverse transcription polymerase chain reaction and Western blot was...
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Article
Open AccessIn vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice
Responsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice.
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Article
Dingxin Recipe (定心方) prevents ischemia/reperfusion-induced arrhythmias via up-regulating prohibitin and suppressing inflammatory responses
To identify the underlying mechanisms of the protective effects of Dingxin Recipe (定: 心方, DXR), a Chinese compound prescription that has been used clinically in China for more than 20 years, on ischemia/reperf...
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Article
Open AccessHeightened expression of MICA enhances the cytotoxicity of NK cells or CD8+T cells to human corneal epithelium in vitro
Major-histocompatibility-complex class I-related chain A (MICA) antigens are the ligands of NKG2D, which is an activating or coactivating receptor expressed on human NK cells and CD8+T cells. We sought to determi...
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Open AccessPrevalence of syphilis infection in different tiers of female sex workers in China: implications for surveillance and interventions
Syphilis has made a dramatic resurgence in China during the past two decades and become the third most prevalent notifiable infectious disease in China. Female sex workers (FSWs) have become one of key populat...
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Comparison of risk factors for recurrent respiratory infections between urban and rural preschool children in Yiwu, China
Many studies have shown an association between the risk of increased recurrent respiratory infections and socioeconomic and fostering factors, but often only a few risk factors have been studied. This study ai...
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A comparison of quality of life of early breast cancer patients treated with accelerated partial breast irradiation versus whole breast irradiation in China
To compare quality of life (QoL) of early breast cancer patients treated with either accelerated partial breast irradiation (APBI) or whole breast irradiation (WBI) after breast-conserving therapy in China. Th...
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Article
Open AccessLow-frequency electrotherapy for female patients with detrusor underactivity due to neuromuscular deficiency
The aim of the study was to assess the efficacy of low-frequency electrotherapy (LFE) for female patients with early-stage detrusor underactivity (DUA) due to neuromuscular deficiency.
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Article
Effect of Huannao Yicong Prescription (还脑益聪方) extract on β-Amyloid precursor protein metabolic signal transduction-related protein in brain tissue of dementia model transgenic mouse
To observe the effect of Huannao Yicong Prescription (还脑益聪方, HNYC, a Chinese medical compound) extract on β-amyloid precursor protein (APP) metabolic signal transductionrelated protein kinase C (PKC), tyrosine...
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Article
Clinical efficacy of traditional chinese medicine on acute myocardial infarction—A prospective cohort study
To evaluate the clinical effects of Chinese medicine (CM) on acute myocardial infarction (AMI) with a prospective cohort study.
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Article
Open AccessUtilization of PET-CT in target volume delineation for three-dimensional conformal radiotherapy in patients with non-small cell lung cancer and atelectasis
To investigate the utilization of PET-CT in target volume delineation for three-dimensional conformal radiotherapy in patients with non-small cell lung cancer (NSCLC) and atelectasis.
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Article
Effects of small interfering RNA targeting sphingosine kinase-1 gene on the animal model of Alzheimer’s disease
Alzheimer’s disease (AD) is an age-related, progressive neurodegenerative disorder that occurs gradually and results in memory, behavior, and personality changes. Abnormal sphingolipid metabolism was reported ...
