1,084 Result(s)
-
Chapter and Conference Paper
An Overview of the Chronobiology of Cellular Morphology
Temporal organization at the cellular level is evident for the eukaryote (Edmunds 1978; Ehret 1974; Goodwin 1963; Hastings and Keyman 1965; Hastings and Schweiger 1976; Schweiger et al. 1964; Vanden Driessche ...
-
Chapter and Conference Paper
Aspects of Human Chronopathology
Often in an individual or a group of patients the manifestation of disease or the exacerbation of symptoms is predictable, exhibiting time dependencies (chronopathologies) over 24-hr, 1-month, and 1-year perio...
-
Chapter and Conference Paper
Chronobiology and Nutrition
In this chapter, evidence for biological rhythms in nutrient intake and the manner in which foodstuffs are metabolized is presented. From a chronobiologic perspective, both nutrients and pharmacological agents...
-
Chapter and Conference Paper
Investigative Methodology for Chronobiology
Progress in the develo** science of chronobiology has closely paralleled the emergence of new and improved research methodologies. Methodological requirements for biological rhythm study have been reviewed p...
-
Chapter and Conference Paper
Chronobiology of Cell Proliferation
Traditionally, cell proliferation within mammalian tissues has been assumed to be asynchronous or random. Numerous investigators who have studied this phenomenon have ignored the potential importance of tempor...
-
Chapter and Conference Paper
Clinical Chronopharmacology
The practical significance of biological temporal structure is well illustrated by chronobiologic findings pertaining to the administration of medicines. Metabolic pathways are neither open with the same level...
-
Chapter and Conference Paper
Reduction of Covalent Binding of Aflatoxin B1 to Rabbit Liver DNA After Immunization Against this Carcinogen
The covalent binding of [3H]aflatoxin B1 (AF) to liver DNA was determined, 6h after oral administration to male rabbits. A Covalent Binding Index, CBI (μmol AF/mol DNA-P)/(mmol AF/kg b. w.) = 8,500 was found. Pre...
-
Chapter and Conference Paper
Methadone Affects the Histochemical Pattern of Xenobiotic-Metabolizing Enzymes in the Liver of Pregnant Rats
Enzyme histochemistry performed on the liver of pregnant and non pregnant rats indicates that methadone (ME) does not cause direct damage to the cells. On the other hand, the enzyme aldehyde dehydrogenase was ...
-
Chapter and Conference Paper
Neurotoxicological Profile of Carbon Disulphide After Intraventricular Administration in Rats
The effects of different concentrations of CS2 given into the III cerebral ventricle in rats on behaviour, on GABA content and on glutamate-decarboxylase activity (GAD), the rate limiting step for GABA synthesis,...
-
Chapter and Conference Paper
The Influence of Two Histamine H2-Receptor Antagonists, Cimetidine and Ranitidine, on the Plasma Levels and Clinical Effect of Nifedipine and Metoprolol
In six healthy volunteers pharmacokinetic and pharmacodynamic interaction of metoprolol and nifedipine with Cimetidine and ranitidine was investigated after 1 week of monotherapy with nifedipine and metoprolol...
-
Chapter and Conference Paper
Increased Microsomal Metabolism of n-Hexane in Rat Kidney and Liver After Inhalation of Isopropanol
Inhalation of 200, 2,000, and 8,000 ppm isopropanol for 2 weeks enhanced the in vitro metabolism of n-hexane in microsomal preparations. The formation of the preneurotoxic metabolite 2-hexanol increased 9, 80,...
-
Chapter and Conference Paper
Potentiation of Hexane and Organophosphate Neurotoxicities
Long-term exposure to hexane and acute or accumulative chronic ingestion of many organophosphates induce peripheral neuropathies (Spencer et al. 1980; Johnson 1982). Many cases of similar peripheral neuropathi...
-
Chapter and Conference Paper
Evaluation of the Toxicological Risk in Animals Following the Ingestion of Cheese Obtained from Milk with Added Formaldehyde
The epidemiological evidence concerning the carcinogenicity of formaldehyde (FA) to man, provides no proof of causal relationship between previous exposure and the occurrence of malignant neoplasma. The use of...
-
Chapter and Conference Paper
Young Scientists Award Lecture 1983: Investigations into the Mechanism of Coumarin-Induced Hepatotoxicity in the Rat
The administration of single doses of coumarin to the rat was found to produce hepatic centrilobular necrosis and also to depress a number of hepatic enzyme activities within 24 h. Coumarin-induced liver damag...
-
Chapter and Conference Paper
Different Pathways of Chloroform Metabolism
Chloroform metabolism can occur in liver, under physiological pO2 conditions, with and without participation of O2. Although, under anaerobic conditions the protein covalent binding of CHCl3 metabolites is lowere...
-
Chapter and Conference Paper
The Effects of Radiological Contrast Media on the Reproduction System of the Rat
During preclinical studies on new radiological contrast media the potential effect on reproductive performance and fertility must be evaluated. Two conventional oral cholecystographic agents, iopanoic acid and...
-
Chapter and Conference Paper
The Subchronic Toxicity of 3,5-Dinitro-4-chloro-α,α,α-trifluorotoluene in the Rat
Since 1978 this department has been engaged in carrying out investigations on the acute and subchronic toxicity of 3,5-dinitro- 4-chloro-α,α,α-trifluorotoluene (DNCTT) and 3-nitro-4-chloro- α,α,α-trifluorotoluene...
-
Chapter and Conference Paper
Tolerance to Pituitary-Adrenal Axis Activation by Anticancer Drugs in Normal and Tumour-Bearing Rats
Cisplatinum given intravenously (i.V.), hydroxyurea given orally (os), procarbazine (os) and L-asparaginase (i.V.), on a decreasing scale, produce significant (p< 0.01) adrenocortical activation over 4-h period a...
-
Chapter and Conference Paper
Drug Toxicity and Hormonal Dysfunction
Abnormal levels of hormones can exert profound changes in drug disposition and the number and affinity of receptors. In endocrine diseases a variety of organ functions change. These disease related changes in ...
-
Chapter and Conference Paper
Erythrocyte-Dependent Metabolic Activation of Styrene and Induction of Sister Chromatid Exchange in Cultured Human Lymphocytes
Human erythrocytes can oxidize styrene to styrene-7,8-oxide in the absence of the co-factors required for metabolic reactions catalysed by the microsomal cytochrome P-450 system. This probably explains the inc...
