Abstract
Enzyme histochemistry performed on the liver of pregnant and non pregnant rats indicates that methadone (ME) does not cause direct damage to the cells. On the other hand, the enzyme aldehyde dehydrogenase was decreased in the periportal tract of the liver lobule of pregnant rats treated with 10 mg/kg ME for 20 days. NADPH dehydrogenase was increased in the central areas of the liver lobule within 3 days of ME treatment. It is suggested that a derangement of xenobiotic metabolizing enzymes in the liver, as well as in other organs, may be contribute to some of the alterations observed in ME treated animals.
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Abbreviations
- ME:
-
methadone
- ALDH:
-
aldehyde dehydrogenase
- NADPH-DH:
-
nicotinamide adenine dinucleotide phosphate dehydrogenase
References
Bellward GD, Gontovnick LS, Otten M (1977) Induction of hepatic aryl hydrocarbon hydroxylase and epoxide hydratase in Wistar rats pretreated with oral methadone hydrochloride. Drug Metab Dispos 5:211–218
Chayen J, Altman FP, Butcher RG (1973a) The effect of certain drugs on the production and possible utilization of reducing equivalents outside the mitochondria. In: Dikstein S (ed) Fundamentals of cell pharmacology. Thomas, Springfield, pp 196–230
Chayen J, Bitensky L, Butcher R (eds) (1973b) Practical histochemistry. John Wiley, London, pp 210–212
Chieco P, Moslen MT, Reynolds ES (1982) Histochemical evidence that plasma and mitochondrial membranes are primary foci of hepatocellular injury caused by 1,1 dichloroethylene. Lab Invest 46:413–421
Crow KE, Cornell NW, Veech RL (1977) The rate of ethanol metabolism in isolated rat hepatocytes. Alcoholism: Exp Clin Res 1: 43–47
Hutchings DE (1982) Methadone and heroin during pregnancy: a review of behavioral effects in human and animal offspring. Neurobehav Toxicol Teratol 4: 429–434
Lieber CS, DeCarli LM (1970) Hepatic microsomal ethanol-oxidizing system. J Biol Chem 245:2505–2512
Masten LW, Peterson GR, Burkhalter A, Way EL (1974) Effect of oral administration of methadone on hepatic microsomal mixed function oxidase activity in mice. Life Sci 14:1635–1640
Needham WP, Sinister L, Kanel GC, Thompson ML (1981) Liver damage from narcotics in mice. Toxicol Appl Pharmacol 58: 157–170
Ornstein L (1952) The distributional error in microspectrophotometry. Lab Invest 1: 250–262
Spaulding TC, Minium L, Kotake AN, Takemori AE (1974) The effect of diazepam on the metabolism of methadone by the liver of methadone-dependent rats. Drug Metab Dispos 2: 458–463
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© 1984 Springer-Verlag
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Chieco, P., Hrelia, P., Candeletti, S., Ferri, S., Forti, G.C. (1984). Methadone Affects the Histochemical Pattern of Xenobiotic-Metabolizing Enzymes in the Liver of Pregnant Rats. In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_40
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DOI: https://doi.org/10.1007/978-3-642-69132-4_40
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12452-8
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