404 Result(s)

Article

Heparin-binding EGF-like growth factor and miR-1192 exert opposite effect on Runx2-induced osteogenic differentiation

Osteoblast differentiation is a pivotal event in bone formation. Runt-related transcription factor-2 (Runx2) is an essential factor required for osteoblast differentiation and bone formation. However, the unde...

S Yu, Q Geng, J Ma, F Sun, Y Yu, Q Pan, A Hong in Cell Death & Disease (2013)

Article

Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer

This study was performed to investigate the role of galectin-1 (Gal-1) in epithelial ovarian cancer (EOC) progression and chemoresistance. Tissue samples from patients with EOC were used to examine the correla...

P Zhang, P Zhang, B Shi, M Zhou, H Jiang, H Zhang, X Pan, H Gao… in Cell Death & Disease (2014)

Article

A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis

The oncoprotein c-Myc is a key transcription factor with essential functions in the nucleolus (NO) to regulate ribosomal RNA (rRNA) synthesis, ribosome biogenesis, and cell proliferation. Yet, the mechanism th...

P Liao, W Wang, M Shen, W Pan, K Zhang, R Wang, T Chen, Y Chen… in Cell Death & Disease (2014)

Article

MicroRNA-181a-mediated downregulation of AC9 protein decreases intracellular cAMP level and inhibits ATRA-induced APL cell differentiation

AC9 is one of the adenylate cyclase (AC) isoforms, which catalyze the conversion of ATP to cAMP, an important second messenger. We previously found that the integration of cAMP/PKA pathway with nuclear recepto...

L K Zhuang, G P Xu, X R Pan, Y J Lou, Q P Zou, D **a, W W Yan… in Cell Death & Disease (2014)

Article

Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib

Microtubule-binding agents, such as taxanes and vinca alkaloids, are used in the treatment of cancer. The limitations of these treatments, such as resistance to therapy and the need for intravenous administrat...

A-C Tsai, C-Y Wang, J-P Liou, H-C Pai, C-J Hsiao, J-Y Chang… in Cell Death & Disease (2014)

Article

The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice

Self-renewal and differentiation of spermatogonial stem cells (SSCs) are the foundation of spermatogenesis throughout a male’s life. SSC transplantation will be a valuable solution for young male patients to p...

J An, X Zhang, J Qin, Y Wan, Y Hu, T Liu, J Li, W Dong, E Du, C Pan… in Cell Death & Disease (2014)

Article

CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis

Cancer/testis antigen (CTA)-45 family (CT45) belongs to a new family of genes in phylogenetics and is absent in normal tissues except for testis, but is aberrantly overexpressed in various cancer types. Whethe...

B Shang, A Gao, Y Pan, G Zhang, J Tu, Y Zhou, P Yang, Z Cao, Q Wei… in Cell Death & Disease (2014)

Article

Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a major malignant tumor of the head and neck region in southern China. The understanding of its underlying etiology is essential for the development of novel effective therapi...

J Ma, F Sun, C Li, Y Zhang, W **ao, Z Li, Q Pan, H Zeng, G **ao… in Cell Death & Disease (2014)

Article

The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxB

The human myxovirus-resistance protein B (MxB, also called Mx2) was recently reported to inhibit HIV-1 infection by impeding the nuclear import and integration of viral DNA. However, it is currently unknown wh...

Zhenlong Liu, Qinghua Pan, Zhibin Liang, Wentao Qiao, Shan Cen, Chen Liang in Retrovirology (2015)

Article

Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth

Sonic hedgehog (Shh) functions as a conserved morphogen in the development of various organs in metazoans ranging from Drosophila to humans. Here, we have investigated the potential roles and underlying mechanism...

Y B Pan, Y Gong, H F Ruan, L Y Pan, X K Wu, C Tang, C J Wang… in Cell Death & Disease (2015)

Article

In vitro activity of dolutegravir against wild-type and integrase inhibitor-resistant HIV-2

Dolutegravir recently became the third integrase strand transfer inhibitor (INSTI) approved for use in HIV-1–infected individuals. In contrast to the extensive dataset for HIV-1, in vitro studies and clinical ...

Robert A Smith, Dana N Raugi, Charlotte Pan, Papa Salif Sow, Moussa Seydi… in Retrovirology (2015)

Article

Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation

Peroxisome proliferator-activated receptors (PPARs) participate in energy homeostasis and play essential roles in diabetes therapy through their effects on non-pancreas tissues. Pathological microenvironment m...

L Li, T Li, Y Zhang, Z Pan, B Wu, X Huang, Y Zhang, Y Mei, L Ge… in Cell Death & Disease (2015)

Article

Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT

Gefitinib efficiency in non-small-cell lung cancer (NSCLC) therapy is limited due to development of drug resistance. The molecular mechanisms of gefitinib resistance remain still unclear. In this study, we fir...

J Yang, G Qin, M Luo, J Chen, Q Zhang, L Li, L Pan, S Qin in Cell Death & Disease (2015)

Article

Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling

Renal fibrosis, particularly tubulointerstitial fibrosis is considered to be the final manifestation of almost all chronic kidney diseases (CKDs). Herein we demonstrated evidence that CHOP-related ER stress is...

M Zhang, Y Guo, H Fu, S Hu, J Pan, Y Wang, J Cheng, J Song, Q Yu… in Cell Death & Disease (2015)

Article

A novel bovine leukemia virus peptide vaccine targeting susceptible cattle-Estimating vaccine effectiveness using susceptible cattle constructed by fertilized ovum transplantation

Shin-nosuke Takeshima, Lanlan Bai, Pan He, Yuki Matsumoto, Junko Kohara… in Retrovirology (2015)

Article

Analysis of CD8⁺ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment

Regulatory T (Treg) cells may participate in mediating a suppressive microenvironment that blunts successful anti-tumor immunotherapy. Recent studies show that CD8⁺ Treg cells might impede effective immune respon...

Shu** Zhang, **ng Ke, Suyun Zeng, Meng Wu… in Cellular & Molecular Immunology (2015)

Article

Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21^Cip1/Waf1

Dysregulated cell cycle progression has a critical role in tumorigenesis. Cell division cycle 27 (CDC27) is a core subunit of the anaphase-promoting complex/cyclosome, although the specific role of CDC27 in ca...

L Qiu, J Wu, C Pan, X Tan, J Lin, R Liu, S Chen, R Geng, W Huang in Cell Death & Disease (2016)