77 Result(s)

Article

From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism

Alternative splicing (AS) is an important approach for pathogens and hosts to remodel transcriptome. However, tuberculosis (TB)-related AS has not been sufficiently explored. Here we presented the first landsc...

Mengyuan Lyu, Jian Zhou, Yanbing Zhou… in Signal Transduction and Targeted Therapy (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articula...

Qing Yao, **aohao Wu, Chu Tao, Weiyuan Gong… in Signal Transduction and Targeted Therapy (2023)

Article

Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets

Autophagy is a conserved lysosomal degradation pathway where cellular components are dynamically degraded and re-processed to maintain physical homeostasis. However, the physiological effect of autophagy appea...

Feng Shu, Han **ao, Qiu-Nuo Li, **ao-Shuai Ren… in Signal Transduction and Targeted Therapy (2023)

Article

Signaling pathways and therapeutic interventions in gastric cancer

Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death. Despite tremendous progress in diagnosis and therapeutic strategies and significant improvements in patient surviv...

Zi-Ning Lei, Qiu-Xu Teng, Qin Tian, Wei Chen… in Signal Transduction and Targeted Therapy (2022)

Article

Deciphering transcriptome alterations in bone marrow hematopoiesis at single-cell resolution in immune thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder, in which megakaryocyte dysfunction caused by an autoimmune reaction can lead to thrombocytopenia, although the underlying mechanisms remain unclear. Her...

Yan Liu, **nyi Zuo, Peng Chen, **ang Hu… in Signal Transduction and Targeted Therapy (2022)

Article

Correction to: NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

Tengfei Fan, **aoning Wang, Sheng Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8⁺ T cells, is regulated by several intrinsic signaling pathways....

Fan Liang, Gui-Zhen Wang, Yan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis

Fengwu Chen, Kaijian Hou, Zhe-Sheng Chen in Signal Transduction and Targeted Therapy (2022)

Article

Correction To: Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Chuan Qin, Sheng Yang, Yun-Hui Chu, Hang Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes of death and disability worldwide. Thus, it is of great nec...

Chuan Qin, Sheng Yang, Yun-Hui Chu, Hang Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

The persistent COVID-19 pandemic since 2020 has brought an enormous public health burden to the global society and is accompanied by various evolution of the virus genome. The consistently emerging SARS-CoV-2 ...

Cong Sun, Chu **e, Guo-Long Bu, Lan-Yi Zhong… in Signal Transduction and Targeted Therapy (2022)

Article

Chronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar

Spinal cord injury (SCI) is a severe damage usually leading to limb dysesthesia, motor dysfunction, and other physiological disability. We have previously shown that NT3-chitosan could trigger an acute SCI rep...

Can Zhao, Jia-Sheng Rao, Hongmei Duan, Peng Hao… in Signal Transduction and Targeted Therapy (2022)

Article

A heme-activatable probe and its application in the high-throughput screening of Plasmodium falciparum ring-stage inhibitors

Sheng Liu, Chunyan Wei, Tian Liu… in Signal Transduction and Targeted Therapy (2022)

Article

NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy, and metastasis accounts for the poor prognosis of OSCC. Autophagy is considered to facilitate OSCC development by mitigating vari...

Tengfei Fan, **aoning Wang, Sheng Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Microbiota in health and diseases

The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, microbiota can be classified into gut, oral, respiratory, and ski...

Kaijian Hou, Zhuo-Xun Wu, Xuan-Yu Chen… in Signal Transduction and Targeted Therapy (2022)

Article

PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice

Yuqing Wang, Jun Du, Shanshan Lu, **a Li… in Signal Transduction and Targeted Therapy (2022)

Article

Redox signaling-governed drug-tolerant persister cancer cell: a key spark of treatment failure

Liwu Fu, Zhe-Sheng Chen in Signal Transduction and Targeted Therapy (2022)

Article

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding

Sheng Lin, Zimin Chen, **ndan Zhang, Ao Wen… in Signal Transduction and Targeted Therapy (2022)

Article

Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants

SARS-CoV-2 variants have evolved a variety of critical mutations, leading to antigenicity changes and immune escape. The recent emerging SARS-CoV-2 Omicron variant attracted global attention due to its signifi...

Cong Sun, Yin-Feng Kang, Yuan-Tao Liu… in Signal Transduction and Targeted Therapy (2022)