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  1. No Access

    Article

    Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling

    Resistance to chemotherapy is believed to be a major cause of treatment failure in pancreatic cancer. Thus, it is necessary to explore alternative therapeutic modalities to overcome drug resistance in pancreat...

    I Ischenko, P Camaj, H Seeliger, A Kleespies, M Guba, E N De Toni, B Schwarz… in Oncogene (2008)

  2. No Access

    Article

    Influence of surgical trauma on the mRNA expression of sex hormone receptors in PBMCs in male and female patients

    Gender-specific immune responses have been found after trauma-hemorrhage. Male and female sex hormones seem to be responsible for this gender dimorphism. Alterations in sex hormone receptor expression in mice ...

    S. A. Brechenmacher, C. J. Bruns, N. K. Van den Engel… in Langenbeck's Archives of Surgery (2008)

  3. No Access

    Article

    Traumatische thorakale Aortenruptur

    Die traumatische thorakale Aortenruptur stellt eine lebensbedrohliche Verletzung der Aorta dar, die als Begleitverletzung nach stumpfem Thoraxtrauma oder im Rahmen eines Polytraumas vorkommen kann. In Abhängig...

    Dr. R. Kopp, J. Andrassy, S. Czerner, A. Weidenhagen, R. Weidenhagen… in Der Anaesthesist (2008)

  4. No Access

    Article

    OsiriX

    Vor der Implantation endovaskulärer Aortenstents ist das Mehrzeilen-Angio-CT heute akzeptierter Standard der präoperativen Planung. Mit Hilfe multiplanarer Rekonstruktionen der CT-Daten werden Längenausdehnung...

    Dr. R. Weidenhagen, G. Meimarakis, K.-W. Jauch, C.R. Becker, R. Kopp in Gefässchirurgie (2008)

  5. No Access

    Article

    Extrathorakal zervikal-endovaskuläre Hybridoperationen zur Behandlung der symptomatischen und/oder aneurysmatischen A. lusoria

    Die sog. A. lusoria stellt als aberrant verlaufende rechte A. subclavia die häufigste Abgangsvariante der Gefäße des Aortenbogens dar. Während diese Gefäßanomalie in den meisten Fällen symptomfrei bleibt, treten ...

    Dr. R. Kopp, S. Däbritz, R. Weidenhagen, M. Steck, L. Lauterjung… in Gefässchirurgie (2008)

  6. Article

    Transoral diverticulostomy with a modified Endo-Gia stapler: results after 4 years of experience

    R. A. Lang, F. W. Spelsberg, H. Winter, K.-W. Jauch, T. P. Hüttl in Surgical Endoscopy (2008)

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  7. No Access

    Article

    Conversion rate in 300 laparoscopic rectal resections and its influence on morbidity and oncological outcome

    The negative influence of conversion from laparoscopic to open colorectal resection on early postoperative morbidity and outcome has been demonstrated several times. In this study, we analyzed the conversion r...

    A. Agha, A. Fürst, I. Iesalnieks… in International Journal of Colorectal Disease (2008)

  8. No Access

    Article

    Elektive Kolonresektionen in Deutschland

    Die „Fast-Track“-Rehabilitation im Rahmen elektiver Kolonresektionen ist ein multimodales, perioperatives Behandlungskonzept, das chirurgische und anästhesiologische Aspekte kombiniert. Dadurch wird die Rate a...

    Dr. T. Hasenberg, M. Niedergethmann, P. Rittler, S. Post, K.W. Jauch… in Der Anaesthesist (2007)

  9. No Access

    Article

    Laparoscopic colonoscopic rendezvous procedures for the treatment of polyps and early stage carcinomas of the colon

    Endoscopic treatment of large or colonoscopically inaccessible polyps or early stage tumors in the colon holds the risk of incomplete resection and colonic perforation. The combination of colonoscopy and lapar...

    H. Winter, R. A. Lang, F. W. Spelsberg… in International Journal of Colorectal Disease (2007)

  10. No Access

    Article

    Imaging of aortic abnormalities with contrast-enhanced ultrasound. A pictorial comparison with CT

    Aortic abnormalities are commonly encountered and may represent a diagnostic challenge in patients with acute or chronic clinical symptoms. Contrast-enhanced ultrasound (CEUS) with low mechanical index (low MI...

    D.-A. Clevert, M. Stickel, T. Johnson, C. Glaser, D.-A. Clevert… in European Radiology (2007)

  11. Article

    Open Access

    Adjuvant therapeutic vaccination in patients with non-small cell lung cancer made lymphopenic and reconstituted with autologous PBMC: first clinical experience and evidence of an immune response

    Given the considerable toxicity and modest benefit of adjuvant chemotherapy for non-small cell lung cancer (NSCLC), there is clearly a need for new treatment modalities in the adjuvant setting. Active specific...

    Dominik Rüttinger, Natasja K van den Engel… in Journal of Translational Medicine (2007)

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    Article

    Umfrage zur perioperativen Therapie bei elektiven Kolonresektionen in Deutschland 2006

    Durch das Fast-Track-Konzept in der Kolonchirurgie lässt sich eine sehr rasche Genesung der Patienten erreichen. Dies ist wegen der guten Evidenz allgemein anerkannt. Dennoch ist die Verbreitung und Anwendung ...

    Dr. T. Hasenberg, P. Rittler, S. Post, K.W. Jauch, M. Senkal, C. Spies… in Der Chirurg (2007)

  13. No Access

    Article

    Cushing-Syndrom mit beidseitiger knotiger Nebennierenvergrößerung

    Die AIMAH („ACTH-independent macronodular bilateral adrenal hyperplasia“) stellt eine seltene Ursache des endogenen Cushing-Syndroms dar. Einhergehend mit einer bilateralen massiven Vergrößerung der Nebenniere...

    M. op den Winkel, C.J. Auernhammer, K.W. Jauch, G. Assmann, C. Dietz… in Der Internist (2007)

  14. No Access

    Article

    Laparoscopic mesh repair of incisional hernia: an alternative to the conventional open repair?

    Tension-free incisional hernia repair using alloplastic material increasingly replaces conventional repair techniques. This change resulted in a decreased recurrence rate (50% vs. 10%, respectively). Recently,...

    M. Stickel, M. Rentsch, D.-A. Clevert, T. Hernandez-Richter, K. W. Jauch, F. Löhe… in Hernia (2007)

  15. No Access

    Article

    Empathie in der Chirurgie

    Obgleich die Bedeutung der Empathie für die Arzt-Patient-Beziehung immer wieder betont wird, gibt es hierzu kaum empirische Untersuchungen. In vorliegender Studie wurden Chirurgen in einer ersten Datenerhebung...

    Dr. phil. Dipl. Psych. K. Burghofer, C.K. Lackner, K.-W. Jauch in Der Chirurg (2007)

  16. No Access

    Article

    Contrast-Enhanced Ultrasound in Detection and Follow-Up of an Infrarenal Abdominal Aortic Aneurysm with Aorto-Caval Fistula and Endovascular Treatment

    An aorto-caval fistula is a rare complication of a symptomatic or ruptured infrarenal aortic aneurysm having a frequency of 3–6%. Patients typically present with clinical signs of diffuse abdominal pain associ...

    D.-A. Clevert, M. Stickel, P. Flach… in CardioVascular and Interventional Radiology (2007)

  17. No Access

    Article

    Secular trends in severe renal failure associated with the use of new antimicrobial agents in critically ill surgical patients

    Randomized controlled trials conducted since 2000 have shown that new antibacterial and antifungal agents may reduce the frequency of kidney injury in selected groups of critically ill patients, yet it is uncl...

    M. E. Eichhorn, H. Wolf, H. Küchenhoff… in European Journal of Clinical Microbiology … (2007)

  18. No Access

    Article

    Depressed T cell-derived IFN-γ following trauma-hemorrhage: a potential mechanism for diminished APC responses

    Prolonged immunosuppression has been demonstrated after trauma-hemorrhage resulting in an increased susceptibility to sepsis. The contribution of antigen-presenting cells (APC) vs T cells to this diminished im...

    C. R. Walz, S. Zedler, C. P. Schneider, S. Mayr… in Langenbeck's Archives of Surgery (2007)

  19. No Access

    Article

    Angiogenesis in cancer: molecular mechanisms, clinical impact

    Angiogenesis, the formation of new blood vessels from the endothelium of the existing vasculature, is fundamental in tumor growth, progression, and metastasis. Inhibiting tumor angiogenesis is a promising stra...

    M. E. Eichhorn, A. Kleespies, M. K. Angele, K.-W. Jauch… in Langenbeck's Archives of Surgery (2007)

  20. No Access

    Article

    Transoral diverticulostomy with a modified Endo-Gia stapler: results after 4 years of experience

    The incidence of Zenker’s diverticulum is low (2/100,000). Standard surgical treatment is cricopharyngeal myotomy with diverticulectomy. Various minimally invasive surgical approaches pursued recently have tre...

    R. A. Lang, F. W. Spelsberg, H. Winter, K.-W. Jauch, T. P. Hüttl in Surgical Endoscopy (2007)

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