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Chapter
Akuter Thorax
Leitsymptom für die Diagnose akuter Thorax ist meist ein thorakaler oder sich auf den Thorax projizierender Schmerz. Thorakale Schmerzen werden häufig von dem Patienten auf das Herz projiziert. Da es sich um e...
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Article
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response
Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy; however, the mechanisms underlying the therapeutic benefit of myeloid-targeting agents in combination with...
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Article
Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy
A collaborative think tank involving panellists from immuno-oncology networks, clinical/translational investigators and the pharmaceutical industry was held in Siena, Italy, in October 2017 to discuss the evol...
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Article
Open AccessColony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
The tumor-permissive and immunosuppressive characteristics of tumor-associated macrophages (TAM) have fueled interest in therapeutically targeting these cells. In this context, the colony-stimulating factor 1 ...
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Protocol
Future of Cancer Vaccines
Extensive research in the area of active-specific immunotherapy has led to the approval of the first therapeutic cancer vaccine sipuleucel-T (Provenge™) in 2010. Even though a major milestone for the field of ...
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Article
Open AccessCombination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer
Active-specific immunotherapy used as an adjuvant therapeutic strategy is rather unexplored for cancers with poorly characterized tumor antigens like gastric cancer. The aim of this study was to augment a ther...
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Article
Dendritic cell-based vaccination of patients with advanced pancreatic carcinoma: results of a pilot study
Dendritic cell (DC)-based vaccination can induce antitumor T cell responses in vivo. This clinical pilot study examined feasibility and outcome of DC-based tumor vaccination for patients with advanced pancreat...
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Chapter
Bispecific T Cell Engager for Cancer Therapy
Treatment with monoclonal antibodies of the human IgG1 and IgG2 isotypes have become a mainstay in cancer therapy, particularly, in hematological malignancies (Ball and Broome 2010). Engagement of Fcγ receptor...
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Article
Open AccessSide-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies
Epithelial cell adhesion molecule (EpCAM) is frequently and highly expressed on human carcinomas. The emerging role of EpCAM as a signalling receptor and activator of the wnt pathway, and its expression on tum...
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Article
Predictors of general complications after video-assisted thoracoscopic surgical procedures
The video-assisted thoracoscopic approach has become the preferred method for many procedures due to the reduced trauma, complication rate and morbidity. The aim of this study was a risk evaluation of patients...
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Article
Open AccessTherapeutic T cells induce tumor-directed chemotaxis of innate immune cells through tumor-specific secretion of chemokines and stimulation of B16BL6 melanoma to secrete chemokines
The mechanisms by which tumor-specific T cells induce regression of established metastases are not fully characterized. In using the poorly immunogenic B16BL6-D5 (D5) melanoma model we reported that T cell-med...
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Article
Open AccessAdjuvant therapeutic vaccination in patients with non-small cell lung cancer made lymphopenic and reconstituted with autologous PBMC: first clinical experience and evidence of an immune response
Given the considerable toxicity and modest benefit of adjuvant chemotherapy for non-small cell lung cancer (NSCLC), there is clearly a need for new treatment modalities in the adjuvant setting. Active specific...
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Article
Regression of bone metastases following adoptive transfer of anti-CD3-activated and IL-2-expanded tumor vaccine draining lymph node cells
As many as 80% of patients with breast, prostate, or lung cancer develop bone metastases during the course of their illness. However, thus far, no attempts have been made to explore the potential value of adop...
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Article
Analysis of the immunological microenvironment at the tumor site in patients with non-small cell lung cancer
Inactivation of tumor-infiltrating lymphocytes by immunomodulating cytokines shed by tumor cells into the tumor local microenvironment might be a potential escape strategy of various tumors from immune-immedia...
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Chapter
Monitoring of Micro Vascular Hemoglobin Oxygenation in Liver and Skeletal Muscle Tissue of Endotoxin-Exposed Rats Using Reflection Spectrophotometry
Sepsis is considered a disorder of microvascular regulation and increased microcirculatory heterogeneity, producing a mismatch between cellular oxygen requirements and tissue perfusion (Menger et al., 1994; Re...
