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  1. Article

    Open Access

    The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects

    Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC), sorafenib is currently an...

    Weiwei Tang, Ziyi Chen, Wenling Zhang, Ye Cheng… in Signal Transduction and Targeted Therapy (2020)

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  2. No Access

    Article

    STAT3 inhibition reduces toxicity of oncolytic VSV and provides a potentially synergistic combination therapy for hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is a refractory malignancy with a high mortality and increasing worldwide incidence rates, including the United States and central Europe. In this study, we demonstrate that a sp...

    S Marozin, J Altomonte, K A Muñoz-Álvarez, A Rizzani, E N De Toni… in Cancer Gene Therapy (2015)

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    Article

    Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling

    Resistance to chemotherapy is believed to be a major cause of treatment failure in pancreatic cancer. Thus, it is necessary to explore alternative therapeutic modalities to overcome drug resistance in pancreat...

    I Ischenko, P Camaj, H Seeliger, A Kleespies, M Guba, E N De Toni, B Schwarz… in Oncogene (2008)