62 Result(s)
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Article
Isaiah J. Fidler
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Reversal of multidrug resistance in murine fibrosarcoma cells by thioxanthene flupentixol
The purpose of this study was to identify calcium channel and calmodulin antagonists effective in increasing the cytotoxic effects of several chemotherapeutic drugs against UV-2237 murine fibrosarcoma MDR cell...
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Expression of theJE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells
The purpose of this study was to determine whether the expression of theJE/MCP-1 gene encoding for the monocyte chemottractant protein, MCP-1 (also known as monocyte chemotactic and activating factor MCAF, TDCF, ...
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Modulation of tumor cell response to chemotherapy by the organ environment
The outcome of cancer metastasis depends on the interaction of metastatic cells with various host factors. The implantation of human cancer cells into anatomically correct (orthotopic) sites in nude mice can b...
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The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype
Alterations in the immunogenic properties of tumor cells frequently accompany selection for multipledrug-resistant (MDR) variants. Therefore, studies were performed to examine the hypothesis that overexpressio...
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Frozen-thawed human blood monocytes respond reproducibly to activation stimuli: Implications for screening of BRMs
The purpose of this study was to identify the optimal freezing conditions for human blood monocytes to allow their recovery and use forin vitro screening of activation stimuli. Human monocytes separated from buff...
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Metastasis as a consequence of aberrant homeostasis
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Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid)
We have recently begun a phase II trial in patients with osteosarcoma who developed pulmonary metastases during adjuvant chemotherapy or who presented with pulmonary metastases that persisted despite chemother...
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Characterization of the invasive and metastatic phenotype in human renal cell carcinoma
The purpose of these studies was to identify some characteristics of metastatic cells and deficiencies of non-metastatic cells in the heterogeneous SN12 human renal cell carcinoma. The SN12 parental line and s...
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In situ activation of mouse macrophages and therapy of spontaneous renal cell cancer metastasis by liposomes containing the lipopeptide CGP 31362
We determined whether the intravenous administration of multilamellar vesicle liposomes (MLV) containing a lipopeptide analogue of a fragment from the cell wall of gram-negative bacteria (CGP 31 362) can rende...
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New developments in in vivo models of neoplasia
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Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis
Human colon carcinomas (HCC) are heterogeneous for a varriety of biological properties that include invasion and metastasis. The presence of a small subpopulation of cells with a highly metastatic phenotype ha...
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Comparative efficacy of liposomes containing synthetic bacterial cell wall analogues for tumoricidal activation of monocytes and macrophages
We examined the activation to the tumoricidal state of normal mouse peritoneal exudate macrophages, bone marrow macrophages, and human blood monocytes by liposomes containing either lipophilic muramyl tripepti...
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Liposomal delivery of biological response modifiers to macrophages
Macrophages activated to the tumoricidal state can recognize and destroy neoplastic cells and leave normal cells unharmed. Systemic activation of macrophages can be achieved by the intravenous administration o...
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Orthotopic implantation is essential for the selection, growth and metastasis of human real cell cancer in nude mice
Human neoplasms are heterogeneous for a variety of biological properties that include invasion and metastasis. The presence of a small subpopulation of cells with a highly metastatic phenotype has important cl...
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Macrophages and cancer
The uncontrolled growth of metastases resistant to conventional therapeutic modalities is a major cause of death from cancer. Data from our laboratory and others indicate that metastases arise from the nonrand...
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In vivo selection of human renal cell carcinoma cells with high metastatic potential in nude mice
Studies were made to determine whether the orthotopic implantation of human renal cell carcinoma cells (HRCC) into nude mice will produce distant metastases, thus allowing for the selection of variant cells wi...
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Thein vitro invasiveness and interactions with laminin of K-1735 melanoma cells. Evidence for different laminin-binding affinities in high and low metastatic variants
The invasive and metastatic characteristics of cloned cells derived from the K-1735 murine melanoma were investigated. Cell lines which are highly metastatic in mice were found to be invasivein vitro, and to show...
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In vitro activation of tumoricidal properties in mouse macrophages using the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) incorporated in liposomes
We investigated the ability of free or liposome-incorporated synthetic chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) to generate tumoricidal properties in mouse macrophages. As FMLP contains ...
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Destruction of tumor cells by monokines released from activated human blood monocytes: evidence for parallel and additive effects of IL-1 and TNF
The incubation of human peripheral blood monocytes with endotoxins activates the cells to lyse tumorigenic targets directly and also induces the production and release into the culture medium of factors that p...
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Growth in an organ microenvironment as a selective process in metastasis
The purpose of these studies was to determine whether the ability of tumor cells to grow in an organ parenchyma selects for cells with enhanced potential to metastasize to this organ. B16-F1 melanoma cells (wi...
