364 Result(s)

Article

Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing

If and how proteasomes catalyze not only peptide hydrolysis but also peptide splicing is an open question that has divided the scientific community. The debate has so far been based on immunopeptidomics, in vi...

Wai Tuck Soh, Hanna P. Roetschke, John A. Cormican, Bei Fang Teo… in Nature Communications (2024)

Article

Camrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial

The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Patients with N3 nasopharyngeal carcinoma have a high risk of distant m...

Hu Liang, Yao-Fei Jiang, Guo-Ying Liu, Lin Wang, Jian-Wei Wang… in Nature Communications (2024)

Article

Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish

Eosinophils are a group of granulocytes well known for their capacity to protect the host from parasites and regulate immune function. Diverse biological roles for eosinophils have been increasingly identified...

Gaofei Li, Yicong Sun, Immanuel Kwok, Liting Yang, Wanying Wen… in Nature Communications (2024)

Article

Creating amphiphilic porosity in two-dimensional covalent organic frameworks via steric-hindrance-mediated precision hydrophilic-hydrophobic microphase separation

Creating different pore environments within a covalent organic framework (COF) will lead to useful multicompartment structure and multiple functions, which however has been scarcely achieved. Herein we report ...

Shu-Yan Jiang, Zhi-Bei Zhou, Shi-**an Gan, Ya Lu, Chao Liu… in Nature Communications (2024)

Article

Combination strategy exploration for prior treated recurrent or metastatic nasopharyngeal carcinoma in the era of immunotherapy

To assess the efficacy and safety of the combination of immune checkpoint inhibitors (ICIs) and target therapy (anti-angiogenesis or EGFR inhibitors) as a second-line or subsequent treatment for recurrent or m...

Yaofei Jiang, Chun Chen, Guoying Liu, Ting Fang, Nian Lu, Weixin Bei… in Scientific Reports (2024)

Article

Origin of the multi-phasic quenching dynamics in the BLUF domains across the species

Blue light using flavin (BLUF) photoreceptors respond to light via one of nature’s smallest photo-switching domains. Upon photo-activation, the flavin cofactor in the BLUF domain exhibits multi-phasic dynamics...

Yalin Zhou, Siwei Tang, Zi**g Chen, Zhongneng Zhou, Jiulong Huang… in Nature Communications (2024)

Article

Author Correction: Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave

Yun Shan Goh, Siew-Wai Fong, Matthew Zirui Tay, Angeline Rouers… in Scientific Reports (2024)

Article

Publisher Correction: Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort study

Benjamin Bay, Christopher Blaum, Caroline Kellner… in Scientific Reports (2024)

Article

Identification and verification of three autophagy-related genes as potential biomarkers for the diagnosis of psoriasis

Psoriasis vulgaris is the most common form of the four clinical types. However, early diagnosis of psoriasis vulgaris is difficult due to the lack of effective biomarkers. The aim of this study was to screen p...

Ailing Zou, Yongjun Chen, Tangsheng Liu, Ting Yang, Bei Zhou in Scientific Reports (2023)

Article

Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort study

The inflammatory burden as measured by high-sensitivity C-reactive Protein (hsCRP) is recognized as a cardiovascular risk factor, which can however be affected by lifestyle-related risk factors (LRF). Up-to-da...

Benjamin Bay, Christopher Blaum, Caroline Kellner… in Scientific Reports (2023)

Article

In vivo RNA interactome profiling reveals 3’UTR-processed small RNA targeting a central regulatory hub

Small noncoding RNAs (sRNAs) are crucial regulators of gene expression in bacteria. Acting in concert with major RNA chaperones such as Hfq or ProQ, sRNAs base-pair with multiple target mRNAs and form large RN...

Fang Liu, Ziying Chen, Shuo Zhang, Ke**g Wu, Cheng Bei… in Nature Communications (2023)

Article

Enhanced formation of methane hydrate from active ice with high gas uptake

Gas hydrates provide alternative solutions for gas storage & transportation and gas separation. However, slow formation rate of clathrate hydrate has hindered their commercial development. Here we report a for...

Peng **ao, Juan-Juan Li, Wan Chen, Wei-**n Pang, **ao-Wan Peng… in Nature Communications (2023)

Article

Copper assisted sequence-specific chemical protein conjugation at a single backbone amide

Direct, site-specific methods of protein functionalization are highly desirable for biotechnology. However, such methods are challenging due to the difficulty of chemically differentiating a single site within...

Mengzhun Guo, Kai Zhao, Liang Guo, Rui Zhou, Qiuju He, Kuan Lu… in Nature Communications (2023)

Article

Comparison of detection methods for carbonation depth of concrete

This paper presents comprehensive research of the advantages and applicability of various concrete carbonation detection methods. Employing a combination of Phenolphthalein indicator (PI), Thermogravimetric an...

Bei Li, Ye Tian, Guoyi Zhang, Yu Liu, Hui** Feng, Nanguo **… in Scientific Reports (2023)

Article

Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave

Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections...

Yun Shan Goh, Siew-Wai Fong, Matthew Zirui Tay, Angeline Rouers… in Scientific Reports (2023)

Article

Comparative physiochemical and transcriptomic analysis reveals the influences of cross-pollination on ovary and fruit development in pummelo (Citrus maxima)

‘Shui**gmiyou’ pummelo (SJ), one of the most popular fruits in Yunnan province of China, is of relatively low fruit shape (FS) quality. In this study, we compared the FS promoting effects of cross pollination...

Shaohua Wang, Chunrui Long, Hongming Liu, Li Pan, Shizao Yang… in Scientific Reports (2023)

Article

Defining neutralization and allostery by antibodies against COVID-19 variants

The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neu...

Nikhil Kumar Tulsian, Raghuvamsi Venkata Palur, **nlei Qian… in Nature Communications (2023)

Article

Identification of cuproptosis-related gene SLC31A1 and upstream LncRNA-miRNA regulatory axis in breast cancer

Mounting evidence indicate that cuproptosis, a novel form of programmed cell death, contributes to cancer development and progression. However, a comprehensive analysis regarding the expressions, functions, an...

Jia-hao Wu, Tian-cheng Cheng, Bei Zhu, Hai-yan Gao, Lin Zheng… in Scientific Reports (2023)

Article

Prognostic analysis of cutaneous Kaposi sarcoma based on a competing risk model

The data regarding the prognosis of cutaneous Kaposi sarcoma (KS) was limited. The current study aimed to explore the risk factors and develop a predictive model for the prognosis of cutaneous KS patients. Dat...

Bei Qian, Ying Qian, Peng **ao, Liang Guo in Scientific Reports (2023)

Article

Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

Hypertriglyceridemic pancreatitis (HTGP) is featured by higher incidence of complications and poor clinical outcomes. Gut microbiota dysbiosis is associated with pancreatic injury in HTGP and the mechanism rem...

Guanqun Li, Liwei Liu, Tianqi Lu, Yuhang Sui, Can Zhang… in Nature Communications (2023)