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Open AccessA roadmap for ribosome assembly in human mitochondria
Mitochondria contain dedicated ribosomes (mitoribosomes), which synthesize the mitochondrial-encoded core components of the oxidative phosphorylation complexes. The RNA and protein components of mitoribosomes ...
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Open AccessProtein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing
If and how proteasomes catalyze not only peptide hydrolysis but also peptide splicing is an open question that has divided the scientific community. The debate has so far been based on immunopeptidomics, in vi...
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Open AccessInvitroSPI and a large database of proteasome-generated spliced and non-spliced peptides
Noncanonical epitopes presented by Human Leucocyte Antigen class I (HLA-I) complexes to CD8+ T cells attracted the spotlight in the research of novel immunotherapies against cancer, infection and autoimmunity. Pr...
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Open AccessLarge database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes
Proteasomes are the main producers of antigenic peptides presented to CD8+ T cells. They can cut proteins and release their fragments or recombine non-contiguous fragments thereby generating novel sequences, i.e....
