65 Result(s)

Article

Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1

Qiao-ling Ruan, Zhi-chao Wang, Cheng-jiang Wei… in Signal Transduction and Targeted Therapy (2023)

Article

Immunosenescence: molecular mechanisms and diseases

Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence). During agi...

Zaoqu Liu, Qimeng Liang, Yuqing Ren… in Signal Transduction and Targeted Therapy (2023)

Article

SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...

Pan Pan, Weiwei Ge, Zhiwei Lei, Wei luo… in Signal Transduction and Targeted Therapy (2023)

Article

Venetoclax and Azacitidine in Chinese patients with untreated acute myeloid leukemia ineligible for intensive chemotherapy

Leiming **a, Wanlu Tian, Yiming Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infec...

Zhijian Xu, Danrong Shi, Jian-Bao Han, Yun Ling… in Signal Transduction and Targeted Therapy (2023)

Article

Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors

Phosphatidylinositol 3-kinase alpha (PI3Kα) inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma (ESCC). It is of great importance to identify potential biomarkers to predic...

Xu Zhang, Yuxiang Wang, ** Zhang, Yanyan Shen… in Signal Transduction and Targeted Therapy (2023)

Article

Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study

Advanced intrahepatic cholangiocarcinoma (ICC) has a dismal prognosis. Here, we report the efficacy and safety of combining toripalimab, lenvatinib, and gemcitabine plus oxaliplatin (GEMOX) as first-line thera...

Guo-Ming Shi, **ao-Yong Huang, Dong Wu… in Signal Transduction and Targeted Therapy (2023)

Article

The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

Epigenetic regulators are frequently mutated in hematological malignancies including acute myeloid leukemia (AML). Thus, the identification and characterization of novel epigenetic drivers affecting AML biolog...

Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir… in Leukemia (2023)

Article

Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2

Mengwen Huang, **ngchao Pan, **nling Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice

Shushu Zhou, Shimin Yuan, **tao Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis

Pleural and peritoneal metastasis accompanied by malignant pleural effusion (MPE) or malignant ascites (MA) is frequent in patients with advanced solid tumors that originate from the lung, breast, gastrointest...

Qizhi Ma, **a He, Benxia Zhang, Fuchun Guo… in Signal Transduction and Targeted Therapy (2022)

Article

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of ...

Ludi Yang, Ruobing Jia, Tongxin Ge… in Signal Transduction and Targeted Therapy (2022)

Article

Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study

Psoriasis is a common, chronic immune-mediated systemic disease that had no effective and durable treatment. Mesenchymal stem cells (MSCs) have immunomodulatory properties. Therefore, we performed a phase 1/2a...

Lamei Cheng, Siqi Wang, Cong Peng, **ao Zou… in Signal Transduction and Targeted Therapy (2022)

Article

Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis

Metastasis is the leading cause of cancer-related death. The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous...

Fubing Li, Huichun Liang, Hua You, Ji **ao… in Signal Transduction and Targeted Therapy (2022)

Article

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Molecular oxygen (O₂) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is linked to several biological p...

Zhen Luo, Mingfu Tian, Ge Yang, Qiaoru Tan… in Signal Transduction and Targeted Therapy (2022)

Article

Correction to: Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

Chen Li, Zhourui Wu, Liqiang Zhou… in Signal Transduction and Targeted Therapy (2022)

Article

Recombinant human erythropoietin ameliorates cognitive dysfunction of APP/PS1 mice by attenuating neuron apoptosis via HSP90β

Hua-Li Wan, Bing-Ge Zhang, Chongyang Chen… in Signal Transduction and Targeted Therapy (2022)

Article

Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance

Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to hete...

Rongbin Ge, Zongwei Wang, Liang Cheng in npj Precision Oncology (2022)

Article

Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

Spinal cord injury (SCI) involves diverse injury responses in different cell types in a temporally and spatially specific manner. Here, using single-cell transcriptomic analyses combined with classic anatomica...

Chen Li, Zhourui Wu, Liqiang Zhou… in Signal Transduction and Targeted Therapy (2022)