3 Result(s)
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Mikkel Bruhn Schuster
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Article
Open AccessThe histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes
Epigenetic regulators are frequently mutated in hematological malignancies including acute myeloid leukemia (AML). Thus, the identification and characterization of novel epigenetic drivers affecting AML biolog...
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Article
Open AccessTranscription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation
Differentiation of multipotent stem cells into mature cells is fundamental for development and homeostasis of mammalian tissues, and requires the coordinated induction of lineage-specific transcriptional progr...
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Article
Open AccessThe splicing factor RBM25 controls MYC activity in acute myeloid leukemia
Cancer sequencing studies have implicated regulators of pre-mRNA splicing as important disease determinants in acute myeloid leukemia (AML), but the underlying mechanisms have remained elusive. We hypothesized...
