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Article
Prolonged Administration of Atropine or Histamine in a Silicone Rubber Implant
IN the use of drugs, it is often desirable to maintain a constant blood and tissue concentration of chemical for prolonged periods. Several attempts to avoid the ‘sawtooth’ oscillations of drug-levels that acc...
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Chapter
The Action of Inhalation Anesthetics on the Gastrointestinal Tract
Investigations of the action of inhalation anesthetics on the gastrointestinal tract have not kept abreast with studies on other organ systems. There are several reasons for this neglect. The unanesthetized st...
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Article
A unique distribution of laxative-induced spike potentials from the small intestine of the dog
The effects of castor oil and ricinoleic acid on small bowel electrical activity were studied in the fasted conscious dog and were compared to the effects elicited by two nonlaxative oils (triolein and oleic a...
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Chapter
Laxatives: A Review of Their Mechanisms of Action
Laxatives are a heterogeneous group of drugs used to increase the frequency of bowel movements. They have been associated with two distinct effects on the gastrointestinal tract: a laxative-induced smooth musc...
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Chapter
Motility: Methods for in vivo Measurements
The absorption from, and transport down the gastrointestinal tract is an important, integrated function. It is accomplished in spite of the heterogeneous motor functions of various portions of the tract; every...
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Article
Human surface electrogastrograms: AC and DC measurements
Both ac and dc abdominal electrical recordings were made on fasted and fed human subjects using a spatial array of 18 cutaneous, biopotential electrodes. Controlled skin puncture minimized cutaneous potentials...
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Article
Adsorption of Inorganic and Organic Ions to Polycarbophil as a Means of Sustained-Release Dosage Formulation
The adsorption and desorption of drugs and inorganic ions to and from polycarbophil (PC), a polymer, were investigated to determine if PC would be a suitable carrier for sustained-release dosage formulations. ...
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Article
Plant regeneration by organogenesis in Vitis rootstock species
A procedure for the regeneration of Vitis rootstocks plantlets by organogenesis from foliar tissues is described. Leaves from mature plants grown in growth chambers or from plantlets grown in tubes were wounded w...
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Article
Neuroplasticity in the smooth muscle of the myenterically and extrinsically denervated rat jejunum
The objective of this study was to examine the effects of two different denervation procedures on the distribution of nerve fibers and neurotransmitter levels in the rat jejunum. Extrinsic nerves were eliminat...
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Article
Differences in the reducing power along the rat GI tract: Lower antioxidant capacity of the colon
The ability of the gastrointestinal (GI) tract, as well as other tissues, to cope with reactive oxygen species (ROS) efflux in pathological events is determined partly by epithelial antioxidant levels. These l...
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Article
Relation Between Colonic Inflammation Severity and Total Low-Molecular-Weight Antioxidant Profiles in Experimental Colitis
Tissue antioxidant status is altered as a response to oxidative stress. This oxidative stress, caused by reactive oxygen species, is associated with inflammatory bowel disease (IBD). Our aim was to examine the...
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Article
The Effect of Local Attachment of Cationized Antioxidant Enzymes on Experimental Colitis in the Rat
Purpose. To investigate the possibility of local treatment of colitis with the adhesive antioxidant enzymes catalase and superoxide dismutase (SOD).
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Article
Intestinal Regrowth Is Amplified After Jejunal but Not Ileal Resection During Tapeworm Infection in the Rat
The ileum possesses functions required by a healthy individual that are not fully supplanted by the duodenum or jejunum. Evidence suggests that the ileum may also be necessary to maintain an enteric parasite–h...
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Article
Tubulointerstitial nephritis and uveitis in monozygotic twin boys
We describe monozygotic male twins who developed tubulointerstitial nephritis and uveitis (TINU) almost 2 years apart. They presented with non-specific symptoms and were noted to have glycosuria and renal impa...
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Article
Acute renal failure in a patient with paroxysmal cold hemoglobinuria
Acute renal failure following auto-immune hemolysis is rare. We report a child with acute paroxysmal cold hemoglobinuria (PCH) complicated by renal failure. She was treated by peritoneal dialysis and red blood...
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Article
Stem cell marker TRA-1-60 is expressed in foetal and adult kidney and upregulated in tubulo-interstitial disease
The kidney has an intrinsic ability to repair itself when injured. Epithelial cells of distal tubules may participate in regeneration. Stem cell marker, TRA-1-60 is linked to pluripotency in human embryonic st...
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Article
Open AccessDNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8+ T-cell responses and increases PSA doubling time
We report on the immunogenicity and clinical effects in a phase I/II dose escalation trial of a DNA fusion vaccine in patients with prostate cancer. The vaccine encodes a domain (DOM) from fragment C of tetanu...
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Article
Open AccessFainting Fanconi syndrome clarified by proxy: a case report
Rare diseases may elude diagnosis due to unfamiliarity of the treating physicians with the specific disorder. Yet, advances in genetics have tremendously enhanced our ability to establish specific and sometime...
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Article
Open AccessMaternal anemia is a potential risk factor for anemia in children aged 6–59 months in Southern Africa: a multilevel analysis
The effect of maternal anemia on childhood hemoglobin status has received little attention. Thus, we examined the potential association between maternal anemia and childhood anemia (aged 6–59 months) from sele...
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Article
Open AccessTubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease
Iron is suggested to play a detrimental role in the progression of chronic kidney disease (CKD). The kidney recycles iron back into the circulation. However, the localization of proteins relevant for physiolog...
