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Acute renal failure in a patient with paroxysmal cold hemoglobinuria

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Abstract

Acute renal failure following auto-immune hemolysis is rare. We report a child with acute paroxysmal cold hemoglobinuria (PCH) complicated by renal failure. She was treated by peritoneal dialysis and red blood cell transfusion. After 2 weeks she had made a complete recovery with a normal blood count and renal profile, and the peritoneal dialysis catheter was removed. Extensive investigation, including an analysis of heme oxygenase-1 gene promoter region polymorphisms, failed to identify a cause for the renal failure in this patient.

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Acknowledgements

JA and SEH are supported by the British Heart Foundation Grants RG2005/14.

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Authors and Affiliations

  1. Regional Paediatric Nephro-Urology Service, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK

    Daljit K. Hothi & Rodney D. Gilbert

  2. Department of Cell Pathology, Southampton General Hospital, Southampton, UK

    Paul Bass

  3. Paediatric Haematology Service, Southampton General Hospital, Southampton, UK

    Mary Morgan

  4. Centre for Cardiovascular Genetics, Royal Free & University College London Medical School, London, UK

    Jayshree Acharya & Steve E. Humphries

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  1. Daljit K. Hothi
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  2. Paul Bass
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  3. Mary Morgan
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  4. Jayshree Acharya
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  5. Steve E. Humphries
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  6. Rodney D. Gilbert
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Correspondence to Rodney D. Gilbert.

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Hothi, D.K., Bass, P., Morgan, M. et al. Acute renal failure in a patient with paroxysmal cold hemoglobinuria. Pediatr Nephrol 22, 593–596 (2007). https://doi.org/10.1007/s00467-006-0352-7

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  • DOI: https://doi.org/10.1007/s00467-006-0352-7

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