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Chapter and Conference Paper
Alterations of Blood Group Receptors of Erythrocytes in Leukemia — Immunofluorescence Studies
Alterations of blood group receptors in the course of leukemia have been observed for the first time in 1957 by van Loghem et al (7). Thereafter, many authors have reported modifications of all the antigens of...
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Chapter and Conference Paper
Cytological and Cytochemical Analysis of Plasma Clot Cultures and Peripheral Granulocytes Related to Long Term Survival in Childhood ALL and Cancer Patients Under Cytostatica Therapy
Colony number and cytology, the cluster/colony ratio, and the peroxydase reaction were investigated in plasma clot cultures (Stephenson et al. 1971; Hellwege et al. 1978; Biermann et al. 1979) of 45 normal per...
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Article
Adjuvant chemotherapy in osteosarcoma — Effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin
In a cooperative adjuvant chemotherapy study of osteosarcoma (COSS-80), 192 patients were registered from December 1979 to March 1982. Fortyone patients have been excluded from study because of their nonadjuva...
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Chapter and Conference Paper
Persistent Deficiency of Myeloperoxidase and Lactoferrin in Granulopoietic Cells of Patients with Acute Leukemia
Searching for prognostic factors which could help in the management of the therapy of human leukemia, we found marked cytochemical abnormalities in granulopoietic cells in plasma clot cultures of bone marrow a...
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Chapter
Multivariate Analysis of Urinary RNA Catabolites in Malignancies: Cross-Sectional and Longitudinal Studies
It is well known that the mammalian organism handles modified ribonucleosides to a great extent as one-way products. They are liberated in the turnover of RNA molecules. Any reutilization of modified ribonucle...
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Article
Toxicity associated with combination chemotherapy for osteosarcoma: A report of the cooperative osteosarcoma study (COSS 80)
The treatment-associated toxicity in 189 patients entered in the COSS-80 Study was analyzed. The sequential use of high-dose methotrexate (HDMTX) with citrovorum factor rescue (CFR) andcis-platinum may be additiv...
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Chapter and Conference Paper
Myelolactoferrin Index (MLF) and Myelopoiesis During Bacterial Infections and Malignant Diseases
The myelolactoferrin index (MLF) is significantly lowered in patients with bacterial infections and with malignant diseases. In both cases it can be assumed that the alteration of the granulopoietic storage po...
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Article
CPO—Cooperative ewing's sarcoma study 1981 (CESS 81): Results after 4 years
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Article
Response kinetic under initial cytostatic treatment according to prognosis of phabdomyosarcoma — A report from the CWS-81 study of the german society of pediatric oncology (GPO)
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Article
Conclusions from the cooperative osteosarcoma (OS) studies COSS-80 and COSS-82 for future therapeutic strategies
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Article
Effectiveness of ifosfamide (IFO) alone and in combination with cisplatinum (DDP) in patients with recurrent ewing's sarcoma
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Chapter and Conference Paper
Early Intensification Therapy in High-Risk Childhood Acute Lymphocytic Leukemia: Lack of Benefit from High-Dose Methotrexate
The prognosis for acute lymphoblastic leukemia (ALL) in childhood has improved considerably in the last two decades. Intensive chemotherapy soon after diagnosis has made a major contribution to this success [3...
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Chapter
The German Pediatric Oncology (GPO) Cooperative Study on Ewing’s Sarcoma
In 1981, the GPO cooperative Ewing’s Sarcoma study (CESS-81) was initiated (1). Patients under the age of 25, with histologically proven diagnosis and without evidence of metastases, received four 9-week cycle...
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Chapter
The German Pediatric Oncology (GPO) Cooperative Study on Osteosarcoma
The GPO has conducted a consecutive series of adjuvant chemotherapy trials in osteosarcoma of the extremities since 1977. Figure 1 shows the outline of the chemotherapy, and Table 1 the global outcome of the d...
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Chapter
Results of the German Soft-Tissue Sarcoma Study
Between 1981 and the end of 1985, 352 children and teenagers with all types of soft-tissue sarcomas were registered in a national multi-center study. Of these, 293 patients were classified under chemosensitive...
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Article
High-dose ifosfamide with mesna uroprotection in Ewing's sarcoma
The German Society of Pediatric Oncology (GPO) has studied the efficacy of high-dose ifosfamide with mesna uroprotection in patients with Ewing's sarcoma. A phase II trial of ifosfamide (IFO) (2 g/m2 per day, day...
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Chapter and Conference Paper
Improved Prognosis for Childhood Acute Lymphocytic Leukemia with Very High White Blood Cell Count (> 100/nl) with Rotation of Non-Cross-Resistant Drug Combinations
Among several initial prognostic factors in acute lymphoblastic leukemia (ALL), i.e., age, hepatosplenomegaly, immunologic subtype, and chromosomal abnormalities [1–4], an elevated white blood count (WBC) at d...
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Chapter and Conference Paper
Conserved Cytotoxic Activity of Aclacinomycin A in Multifactorial Multidrug Resistance
Identification of anthracyclines which are able to overcome multidrug resistance would be a major step towards to improving antineoplastic chemotherapy.
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Chapter and Conference Paper
Prognostic Significance of Exposure to Intermediate-Dose Methotrexate in Children with Standard Risk ALL: The COALL 82/85 Experience
Methotrexate is being widely used in doses ranging from 500 to 2 000 mg administered as prolonged infusion over 12–36 h followed by leucovorin rescue to consolidate remission of acute lymphoblastic leukemia [1...
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Chapter and Conference Paper
Bone Marrow Blast Count at Day 28 as the Single Most Important Prognostic Factor in Childhood Acute Lymphoblastic Leukemia
Intensification of therapy and risk-adapted treatment have increased the cure rates for childhood acute lymphocytic leukemia (ALL) to 60%–70% [1–5]. Among the prognostic parameters the initial white blood coun...
