Experimental Lung Cancer
Carcinogenesis and Bioassays
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Cancer Research
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Article
The Malignancy of Cancer at Different Ages: A Histological Study
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Chapter and Conference Paper
The Pathology of Trophoblastic Tumours
Gestational trophoblast has at least as wide a range of pathological behaviour as any other tissue, and a wider range than most. I believe that this requires emphasis for we are in some danger of holding too n...
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Book
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Chapter
Radiation Carcinogenesis. Introductory Remarks
Nuclear energy is expected to provide a large fraction of the future electrical energy requirements of the world. The projected health risk of nuclear energy, compared to other electrical energy sources, is cu...
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Article
Mathematical modeling of differentiation in dictyostelium discoideum
Methods for the dynamic analysis of biochemical differentiation are presented. These are demonstrated in the analysis of biochemical differentiation of the carbohydrate system inD. discoideum. Procedures for simp...
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Chapter
Biological Assumptions in the Bioassay
The presentations made in the first session were fairly general, which led to a spectrum of comments in the discussion period. Many of the questions raised were addressed in more detail in later sessions.
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Chapter and Conference Paper
B Cell Precursors in Bone Marrow: In Vivo Proliferation, Localization, Stimulation by Activated Macrophages and Implications for Oncogenesis
Precursor cells in mammalian bone marrow continuously give rise to virgin B lymphocytes by undergoing a series of genetic, mitotic and selection events (Osmond 1985, 1986, Osmond & Park 1987). During the diffe...
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Article
Differential permeability of lymphatic and blood vessels in determining the route of metastasis as demonstrated by indirect lymphography
Indirect mammo-lymphography with serial radiograms was made on rats bearing three established rat mammary carcinomas (SMT-2A, TMT-50, MT-W9B), with the water-soluble contrast medium, Iotasul. In the lymphogeno...
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Article
Current status and future aspects on treatment of liver cancer
Among 80 patients with advanced hepatocellular carcinoma, treated by systemic chemotherapy, 19 patients (24%) achieved partial response or stable disease. The median survival time of responders was 20 weeks. R...
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Article
Radioiodinated fatty acid esters in the management of hepatocellular carcinoma: preliminary findings
Radioiodinated fatty acid esters, such as lipiodol or ethiodol, are localized in the hypervascular hepatocellular carcinoma (HCC) for a long time following intra-arterial hepatic injection, enabling delivery o...
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Article
Recombinant interleukin-2 treatment in patients with metastatic colorectal cancer: Effect on natural cytotoxicity
Natural cytotoxicity (natural killer, NK, and lymphokine-activated killer, LAK, activity) was documented in 12 patients with metastatic colorectal cancer, both before and after a 5-day course of continuous the...
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Chapter
Anti-p185HER2 monoclonal antibodies: Biological properties and potential for immunotherapy
It is by now clear that the pathogenesis of human cancer involves the aberrant functioning of the products of oncogenes. In breast and other cancers, the HER2 protooncogene appears to play an important role in...
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Article
The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse
The gene encoding the granulocyte macrophage colony stimulating factor receptor α subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report ...
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Article
Cytotoxic T cell lines recognize autologous and allogeneic melanomas with shared or cross-reactive HLA-A
Cytotoxic T lymphocytes (CTL), CD3+, α/β T-cell-receptor-positive, are important effector cells with specific immunity in melanoma patients. The establishment and expansion in vitro of CTL of a specific phenotype...
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Article
The epidemiology of AIDS-associated non-Hodgkin's lymphoma in the World Health Organization European Region
This paper describes the epidemiology of AIDS-associated non-Hodgkin's lymphoma (NHL) in the World Health Organization (WHO) European Region. Data, collected by the WHO Collaborating Centre on AIDS in Paris, F...
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Article
Interleukin 2 therapy in cancer: identification of responders
C-reactive protein (CRP) levels in serum were measured in fifteen patients with metastatic colorectal carcinoma, prior to and during treatment with a continuous intravenous infusion of rIL.2. Patients were sub...
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Chapter and Conference Paper
Oncogenic Activation of the Met/HGF Receptor Tyrosine Kinase is Promoted by Leucine Zipper Mediated Dimerization
The met receptor tyrosine kinase is oncogenically activated by a genomic rearrangement that results in the production of a 65 kd protein containing tpr sequences fused directly to the met receptor kinase domain.
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Article
The Wilms tumour gene WT1 is expressed in murine mesoderm–derived tissues and mutated in a human mesothelioma
The tumour suppressor gene WT1 encodes a transcription factor expressed in tissues of the genito–urinary system. Inactivation of this gene is associated with the development of Wilms tumour a pediatric kidney ...
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Article
Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour
Nephrogenic rests consist of foci of primitive renal cells, typically microscopic, that are found within the normal kidney tissue of children with Wilms' tumour. To study the relationship between nephrogenic r...
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Article
Small hepatocellular carcinoma: high dose internal radiation therapy with superselective intra-arterial injection of I-131-labeled Lipiodol
The aim of the present study was to deliver a high internal radiation dose to small hepatocellular carcinoma (HCC) lesions in an attempt to treat this disease. A total of 18 patients with HCC lesions measuring...
