Summary
Radioiodinated fatty acid esters, such as lipiodol or ethiodol, are localized in the hypervascular hepatocellular carcinoma (HCC) for a long time following intra-arterial hepatic injection, enabling delivery of high internal radiation to the tumor. The desired radiation can easily be delivered to small HCC, less than 5 cm in diameter, in single or multiple procedures with an 8-week interval. For larger tumors, [131I]lipiodol or [131I]ethiodol in conjunction with chemotherapy emulsion, Ivalon embolization or all three combinations should be considered for maximal clinical results. A strong beta emitter with shorter physical half-life, i.e.90Y will be more effective in the management of HCC if one can label lipiodol with90Y.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bookstein J (1985) Hepatocellular carcinoma: recent advances in diagnosis with iodized oil 54: 253
Iwai K, Kooni T, Maeda H (1980) Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image 44: 2115
Konno K, Maeda H, Iwai K, et al. (1983) Effect of arterial administration of high molecular weight anticancer agent SMANCS with lipid lumphographic agent on hepatoma: a preliminary report 19: 1053
Madson MT, Park CH, Thakur ML, et al. (1987) A dosimetric comparison of I-131, Y-90 and P-32 as radiolabels for ethiodol in the treatment of hepatoma. Presented at american Association of Physicists in Medicine. 29th Annual Meeting, Detroit, Michigan, July 19–23, 1987
Nakakuma K, Tashiro S, Hiraoka T et al. (1985) Hepatocellular carcinoma and metastic cancer detected by iodized oil. Radiology 154, 15
Ohishi H, Uchida H, Yoshimura H, et al. (1985) Hepatocellular carcinoma detected by iodized oil: use of anticancer agents. Radiology 154: 25
Ohnish K, Tsuchya S, Nakayma T, et al. (1984) Arterial chemoembolization of hepatocellular carcinoma with mitomycin C microcapsules. Radiology 152: 51
Park CH, Suh JH, Yoo HS, et al. (1986) Evaluation of intrahepatic I-131 ethiodol on a patient with hepatocellular carcinoma-therapeutic feasibility. Clin Nucl Med 11: 514
Satoh M, Yamada R (1983) Experimental and clinical studies on the hepatic artery embolization for treatment of hepatoma. Nippon Acta Radiol 43: 977 (In Japanese)
Yoo HS, Suh JH, Lee JT, et al. (1986) Therapeutic trial of intrahepatic I-131-lipiodol on patients with hepatocellular carcinoma. Korean J, Gastroenterol 18: 217
Yoo HS, Suh JH, Lee JT, et al. (1986) Therapeutic feasibility study and clinical trial of I-131-lipiodol on patients with hepatocellular carcinoma. Korean Nucl Med 20: 61
Yumoto Y, **nok, Tokuyma K, et al. (1985) Hepatocellular carcinoma detected by iodized oil. Radiology 154: 19
Author information
Authors and Affiliations
Additional information
This work was supported in part by Yonsei Cancer Center Research Grant
Rights and permissions
About this article
Cite this article
Yoo, H.S., Park, C.H., Suh, J.H. et al. Radioiodinated fatty acid esters in the management of hepatocellular carcinoma: preliminary findings. Cancer Chemother. Pharmacol. 23 (Suppl 1), S54–S58 (1989). https://doi.org/10.1007/BF00647241
Issue Date:
DOI: https://doi.org/10.1007/BF00647241