-
Article
Differential permeability of lymphatic and blood vessels in determining the route of metastasis as demonstrated by indirect lymphography
Indirect mammo-lymphography with serial radiograms was made on rats bearing three established rat mammary carcinomas (SMT-2A, TMT-50, MT-W9B), with the water-soluble contrast medium, Iotasul. In the lymphogeno...
-
Article
Dietary 4-HPR suppresses the development of bone metastasis in vivo in a mouse model of prostate cancer progression
The effects of the synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) on prostate cancer metastasis in vivo were evaluated in the mouse prostate reconstitution (MPR) model. MPRs were produced by infection ...
-
Article
Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma
Relevant animal models for metastasis of osteosarcoma is needed to understand the biology and to develop the treatment modality of metastasis of human osteosarcoma. Therefore, we screened six human osteosarcom...
-
Article
Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells
Autotaxin (ATX), originally isolated from human melanoma cells, is a novel metastasis-enhancing motogen and angiogenesis factor. In the present study, we compared the expression level of ATX mRNA between norma...
-
Article
Biological properties and gene expression associated with metastatic potential of human osteosarcoma
Lung metastasis has a great influence on the prognosis of patients with osteosarcoma. We previously established two high-metastatic sublines, M112 and M132, from the HuO9 human osteosarcoma cell line by in vivo s...
-
Article
Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis
A significant fraction of cancer patients have occult disseminated tumors at the time of primary diagnosis, which usually progress to become clinically relevant lesions. Since the majority of cancer mortality ...
-
Article
An Orthotopic Model of Human Osteosarcoma Growth and Spontaneous Pulmonary Metastasis
Osteosarcoma is the most common primary malignancy of bone and patients often develop pulmonary metastases. In order to investigate the pathogenesis of human osteosarcoma, there is a great need to develop a cl...
-
Article
Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study* (United States)
To describe the relationship between the intake of fruits, vegetables, and related vitamins and antioxidants, and the risk of prostate cancer in male participants in a large multiethnic cohort study.
-
Article
Cancer mortality and farming in South Korea: an ecologic study
The aim of this study was to examine the geographical difference of cancer mortality to determine any potential associations between cancer mortality and farming in South Korea.
-
Article
Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study
In order to prospectively investigate physical activity at varying intensities and sedentary behavior in relation to colorectal cancer.
-
Article
Open AccessPhysical activity and head and neck cancer risk
To investigate the relation of physical activity to head and neck cancer.
-
Article
Open AccessHuman hydrocephalus dynamics: loss of normal pulsation absorber mechanism
-
Article
Open AccessInduced canine hydrocephalus alters pulsation absorber characteristics
-
Article
Circulating fatty acids and prostate cancer risk in a nested case–control study: the Multiethnic Cohort
Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting.
-
Article
Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans
We investigated the association of genetic polymorphisms of NQO1, ALDH2, CYP2E1, and the combined genotype of these genes on lung cancer risk, and also evaluated the association after stratification by cumulative...
-
Article
Factors related to second cancer screening practice in disease-free cervical cancer survivors
Although cancer survivors are at increased risk for develo** cancers at other sites, little is known about the current status of second cancer (cancers other than the index cancer) screening practices and re...
-
Article
Open AccessA porcine model of hydrocephalus induced by gamma knife irradiation
-
Article
Non-cancer mortality among long-term survivors of adult cancer in Korea: national cancer registry study
To investigate the pattern of non-cancer deaths and to determine whether there is excess mortality from non-cancer causes among Korean long-term survivors of adult cancer.
-
Article
Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts
To investigate whether the positive association of body mass index (BMI, kg/m2) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes.
-
Article
Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies
To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer.