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Article
Gene expression pathway analysis to predict response to neoadjuvant docetaxel and capecitabine for breast cancer
Neoadjuvant chemotherapy has been shown to be equivalent to post-operative treatment for breast cancer, and allows for assessment of chemotherapy response. In a pilot trial of docetaxel (T) and capecitabine (X...
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Article
The Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival
Microarray expression signature analyses have suggested that extracellular matrix (ECM) gene dysregulation is predictive of metastasis in both mouse mammary tumorigenesis and human breast cancer. We have previ...
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Article
Metastasis Predictive Signature Profiles Pre-exist in Normal Tissues
Previous studies from our laboratory have demonstrated that metastatic propensity is significantly influenced by the genetic background upon which tumors arise. We have also established that human gene express...
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Article
Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis
A significant fraction of cancer patients have occult disseminated tumors at the time of primary diagnosis, which usually progress to become clinically relevant lesions. Since the majority of cancer mortality ...
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Article
Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1