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Article
Manganese superoxide dismutase polymorphism and risk of skin cancer (United States)
We assessed whether the functional V16A polymorphism in the MnSOD gene is associated with skin cancer risk.
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Article
A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS). A single nucleotide polymorphism (SNP) G-463A in t...
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Article
A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
The MDM2 oncoprotein is a key negative regulator of the tumor suppressor p53. A functional MDM2 single nucleotide polymorphism (SNP309) in the promoter region increases the affinity of transcription activator ...
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Article
Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
Purpose We comprehensively evaluated genetic variants in DNA repair genes with premenopausal breast cancer risk. Methods In this nested case–control study of 239 prospectively ascertained premenopausal breast can...
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Article
Open AccessGenetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR...
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Article
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk
Mistakes in DNA repair can result in sustained damage and genetic instability. We comprehensively evaluated common variants in DNA repair pathway genes for their association with postmenopausal breast cancer r...
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Article
ASIP genetic variants and the number of non-melanoma skin cancers
Patients with primary non-melanoma skin cancers (NMSCs) tend to develop these cancers at multiple independent sites. We examined the genetic factors in the development of multiple NMSCs among Caucasian women w...
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Article
Genetic variants in telomere-maintaining genes and skin cancer risk
Telomere-related genes play an important role in maintaining the integrity of the telomeric structure that protects chromosome ends, and telomere dysfunction may lead to tumorigenesis. We evaluated the associa...
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Article
Genome-wide association study identifies three new melanoma susceptibility loci
Timothy Bishop and colleagues of the GenoMEL Consortium report a genome-wide association study for melanoma, identifying three new susceptibility loci.
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Article
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
Stuart MacGregor and colleagues report the results of a genome-wide association study for melanoma susceptibility in an Australian population. They identify a new melanoma susceptibility locus on chromosome 1.
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Article
Sphingosine-1-Phosphate Attenuates Lung Injury Induced by Intestinal Ischemia/Reperfusion in Mice: Role of Inducible Nitric-Oxide Synthase
Multiple organ failure, including acute lung injury (ALI), is a common complication of intestinal ischemia/reperfusion (I/R) injuries and contributes to its high mortality rate. Sphingosine-1-phosphate (S1P) i...
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Article
Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma
Genome-wide association studies (GWASs) have primarily focused on marginal effects for individual markers and have incorporated external functional information only after identifying robust statistical associa...
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Article
Obesity and the incidence of skin cancer in US Caucasians
Limited information is available on the potential link between obesity and either melanoma or non-melanoma skin cancers.
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Article
Open AccessMelanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies
For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a di...
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Article
In Utero and Lactational Lanthanum Exposure Induces Olfactory Dysfunction Associated with Downregulation of βIII-tubulin and Olfactory Marker Protein in Young Rats
We evaluated the role of βIII-tubulin in the morphology of olfactory receptor neuron (ORN) and olfactory dysfunction in offspring caused by prenatal and postnatal lanthanum exposure. Pregnant rats were exposed...
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Article
Obesity-related genetic variants, human pigmentation, and risk of melanoma
Previous biological studies showed evidence of a genetic link between obesity and pigmentation in both animal models and humans. Our study investigated the individual and joint associations between obesity-rel...
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Article
CXCR4 pathway associated with family history of melanoma
Genetic predisposition plays a major role in the etiology of melanoma, but known genetic markers only account for a limited fraction of family-history-associated melanoma cases. Expression microarrays have of...
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Article
A genome-wide association study of severe teenage acne in European Americans
Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 Europea...
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Article
No association between vitamin D intake and incident psoriasis among US women
We investigated the association between dietary, supplementary and total vitamin D intake and incident psoriasis in women. A prospective study was performed of 70,437 US female nurses aged 47–74 enrolled in th...
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Article
Invasive cutaneous squamous cell carcinoma incidence in US health care workers
Little data on cutaneous squamous cell carcinoma (SCC) epidemiology within the United States are currently available. Prior studies have focused on populations outside of the United States or been limited to r...
