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Effect of Glycosylation on the Physicochemical Properties, Structure and Iron Bioavailability of Ferritin Extracted from Tegillarca granosa
Iron deficiency anemia (IDA) is a major global health problem. Tegillarca granosa has been considered as an excellent source of iron given its high...
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Nonenzymatic Reactions in Metabolism: Their Role in Evolution and Adaptation
AbstractMetabolism can be represented as a network of enzymatic and nonenzymatic (spontaneous) biochemical reactions. One of the most important parts...
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Study of the mechanism by gentiopicroside protects against skin fibroblast glycation damage via the RAGE pathway
The occurrence of nonenzymatic glycosylation reactions in skin fibroblasts can lead to severe impairment of skin health. To investigate the...
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Modeling N-Glycosylation: A Systems Biology Approach for Evaluating Changes in the Steady-State Organization of Golgi-Resident Proteins
The organization of Golgi-resident proteins is crucial for sorting molecules within the secretory pathway and regulating posttranslational...
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Unraveling the glycosylated immunopeptidome with HLA-Glyco
Recent interest in targeted therapies has been sparked by the study of MHC-associated peptides (MAPs) that undergo post-translational modifications...
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Acute Glucose Load, Inflammation, Oxidative Stress, Nonenzymatic Glycation, and Screening for Gestational Diabetes
Aims: To investigate if oral glucose tolerance test (OGTT) associates with changes in maternal symptoms (ie, flushing, sweating), blood nonenzymatic...
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EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity
BackgroundThe expression of Egl-9 family hypoxia-inducible factor 3 (EGLN3) is notably decreased in various malignancies, including gastric cancer...
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Fibroblast Activation Protein (FAP): A Key Modulator of the Cancer Microenvironment
Fibroblast activation protein-α (FAP) is a type II transmembrane serine protease with extensive endonuclease activity that is almost undetectable in...
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Correlation between the accumulation of skin glycosylation end products and the development of type 2 diabetic peripheral neuropathy
BackgroundThe accumulation of advanced glycation end products (AGEs) occurring in skin tissues can be measured by AGE Reader. Here, we assessed the...
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D-ribose metabolic disorder and diabetes mellitus
D-ribose, an ubiquitous pentose compound found in all living cells, serves as a vital constituent of numerous essential biomolecules, including RNA,...
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Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is...
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Measures of Endothelial Function in Type 2 Diabetes: A Focus on Circulatory Biomarkers
Endothelial dysfunction occurs early in the development of atherosclerosis and predicts the development of cardiovascular events in T2DM. The...
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Discovery of ER-localized sugar transporters for cellulase production with lac1 being essential
BackgroundIn the process of cellulose hydrolysis, carbohydrate hydrolysates are transported into cells through membrane transporters, and then affect...
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Nitration of Tyrosine and Tyrosyl Residues in Myoglobin by the Action of Visible Light in the Presence of Riboflavin and Nitrite**
The nitration of tyrosyl residues in proteins is considered a type of post-translational modification of proteins, indicating disruptions in the...
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Transgenic Arabidopsis thaliana plants expressing bacterial γ-hexachlorocyclohexane dehydrochlorinase LinA
Backgroundγ-Hexachlorocyclohexane (γ-HCH), an organochlorine insecticide of anthropogenic origin, is a persistent organic pollutant (POP) that causes...
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Measures of Endothelial Function in Type 2 Diabetes: A Focus on Circulatory Biomarkers
Endothelial dysfunction occurs early in the development of atherosclerosis and predicts the development of cardiovascular events in T2DM. The...
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Methylglyoxal Induced Modifications to Stabilize Therapeutic Proteins: A Review
Therapeutic proteins are potent, fast-acting drugs that are highly effective in treating various conditions. Medicinal protein usage has increased in...
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The post-translational modification landscape of commercial beers
Beer is one of the most popular beverages worldwide. As a product of variable agricultural ingredients and processes, beer has high molecular...
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Molecular Mechanisms Underpinning Plant Stress Responses: Insights into the Cellular and Systemic Regulation
Plants are under constant environmental stress including extreme temperature, salinity, drought as well as insect and pathogen problems, which affect...
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Mechanisms of Diabetic Nephropathy in Humans and Experimental Animals
Several major advances over the last years have increased our understanding of the pathogenesis of diabetic kidney disease (DKD), thanks in large...