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Construction of lncRNA-m6A gene-mRNA regulatory network to identify m6A-related lncRNAs associated with the progression of lung adenocarcinoma
BackgroundWe evaluated the prognostic value of m6A-related long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD).
MethodsThe expression levels...
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m6A methyltransferase METTL3 facilitates multiple myeloma cell growth through the m6A modification of BZW2
N6-methyladenosine (m6A) methyltransferase-like 3 (METTL3) has been confirmed to be involved in multiple myeloma (MM) progression, and basic leucine...
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RNA m6A methylation regulators in liver cancer
Liver cancer is one of the most common cancers in the world and a primary cause of cancer-related death. In recent years, despite the great...
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Association between ankylosing spondylitis and m6A methylation
BackgroundN6-methyl adenosine (m6A) is the most common reversible mRNA modification in eukaryotes implicated in key roles in various biological...
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RNA m6A methylation regulators in sepsis
N6-methyladenosine (m6A) modification is a class of epitope modifications that has received significant attention in recent years, particularly in...
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Crosstalk between m6A modification and autophagy in cancer
Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional...
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RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension
m6A (N6‑methyladenosine) is the most common and abundant apparent modification in mRNA of eukaryotes. The modification of m6A is regulated...
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Morphine-Driven m6A Epitranscriptomic Neuroadaptations in Primary Cortical Cultures
Opioid overdose is the leading cause of accidental death in the United States and remains a major public health concern, despite significant...
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Role of m6A RNA Methylation in Ischemic Stroke
Ischemic stroke is a prominent contributor to global morbidity and mortality rates. The intricate and diverse mechanisms underlying...
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The Functions of N-methyladenosine (m6A) Modification on HIV-1 mRNA
In recent years, there has been a growing interest in the study of RNA modifications, with some researchers focusing specifically on the connection...
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Recent advances of m6A methylation in skeletal system disease
Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden....
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Analysis of m6A-regulated genes and subtype classification in lupus nephritis
BackgroundLupus nephritis (LN) is the most common and severe clinical manifestation of systemic lupus erythematosus (SLE). N6-methyladenosine (m6A)...
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Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier
The intestinal lumen acts as a critical interface connecting the external environment with the body’s internal state. It’s essential to prevent the...
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N6‐methyladenosine (m6A) Modification in Preeclampsia
Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of...
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Comprehensive analysis of m6A modification in immune infiltration, metabolism and drug resistance in hepatocellular carcinoma
N6-methyladenosine (m6A) is important in regulating mRNA stability, splicing, and translation, and it also contributes to tumor development. However,...
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METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging
Senile osteoporosis is mainly caused by osteoblasts attenuation, which results in reduced bone mass and disrupted bone remodeling. Numerous studies...
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Comprehensive analysis of m6A modification in lipopolysaccharide-induced acute lung injury in mice
BackgroundN6-Methyladenosine (m6A) methylation is the most prevalent post-transcriptional modification in mRNA, and plays significant roles in...
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Direct Analysis of HIV mRNA m6A Methylation by Nanopore Sequencing
The post-transcriptional processing and chemical modification of HIV RNA are understudied aspects of HIV virology, primarily due to the limited...
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The roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications
Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily attributed to the persistent infection of high-risk Human...
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Implication of m6A Methylation Regulators in the Immune Microenvironment of Bronchopulmonary Dysplasia
N 6 -methyladenosine (m6A) regulates gene expression and governs many important biological processes. However, the function of m6A in the development...
