Search
Search Results
-
Leptin receptor gene deficiency minimally affects osseointegration in rats
Metabolic syndrome represents a cluster of conditions such as obesity, hyperglycaemia, dyslipidaemia, and hypertension that can lead to type 2...
-
Impact of the leptin receptor gene on pig performance and quality traits
The recessive T allele of the missense polymorphism rs709596309 C > T of the leptin receptor gene is associated with intramuscular fat. However, its...
-
Association of polymorphism in leptin receptor gene with susceptibility of adolescent idiopathic scoliosis
PurposeAbnormal leptin bioavailability has play key roles in the etiology of adolescent idiopathic scoliosis (AIS). Both leptin and its receptor...
-
Association of the Human Leptin Receptor Gene (rs1137101; Gln223Arg) Polymorphism and Circulating Leptin in Patients with Metabolic Syndrome in the Indian Population
Phenotypic expression of metabolic syndrome is precipitated by environmental variables along with the individual genetic susceptibility to the...
-
Congenital leptin and leptin receptor deficiencies in nine new families: identification of six novel variants and review of literature
Early childhood obesity is a real public health problem worldwide. Identifying the etiologies, especially treatable and preventable causes, can...
-
Structural insights into the mechanism of leptin receptor activation
Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling...
-
Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children
Leptin influences eating behavior. Exposure to early adversity is associated with eating behaviour disorders and metabolic syndrome, but the role of...
-
Associations of Polymorphisms in Leptin and Leptin Receptor Genes with Meat Quality in Pigs of the Ukrainian Large White Breed
AbstractThe associations of SNP in leptin gene ( LEP g.2845A>T, LEP g.3996T>C, LEP g.3469T>C) and leptin receptor gene ( LEPR c.232A>T, LEPR ...
-
Obstructive Sleep Apnea in an Infant with Suspected Congenital Leptin Hormone Receptor Deficiency
An 8-month-old female child, born of a consanguineous marriage, presented to the Paediatrics department, with complaints of excessive weight gain,...
-
Characterization of adaptive expression regulation of yellowtail kingfish (Seriola lalandi) leptin, receptor, and receptor overlap** transcript genes in response to fasting and re-feeding strategies
Leptins and other related genes have been proven to play vital roles in food intake, weight control, and other life activities. While the function of...
-
Mechanism of receptor assembly via the pleiotropic adipokine Leptin
The adipokine Leptin activates its receptor LEP-R in the hypothalamus to regulate body weight and exerts additional pleiotropic functions in...
-
A fresh look to the phenotype in mono-allelic likely pathogenic variants of the leptin and the leptin receptor gene
Leptin (LEP) and leptin receptor (LEPR) play a major role in energy homeostasis, metabolism, and reproductive function. While effects of biallelic...
-
Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis
Metformin is the biguanide of hepatic insulin sensitizer for patients with non-alcohol fatty liver disease (NAFLD). Findings regarding its efficacy...
-
Association of leptin–melanocortin gene polymorphisms with the risk of obesity in northwest Indian population
BackgroundObesity, a multifaceted endocrine issue, is adversely affecting all age groups and is posing a significant public health challenge. The...
-
Chemical shift assignments of wildtype human leptin
Leptin is an adipose tissue-expressed 16-kDa hormone encoded by the ob/ob gene. It serves a crucial role in regulating diverse physiological...
-
Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport
BackgroundThe hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most...
-
Leptin Fragment 116–122 Modulates Testicular Steroidogenesis in Male Rats
AbstractThe adipokine leptin plays an important role in the regulation of the reproductive system. It stimulates the activity of the...
-
A negative feedback loop between TET2 and leptin in adipocyte regulates body weight
Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to regulate gene expression by oxidizing 5-methylcytosine to...
-
The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population
BackgroundSeveral studies have reported that fat mass and obesity-associated gene (FTO), especially the rs9939609 polymorphism, are associated with...
-
Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice
For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking and consummatory phases. Heterogeneous lateral...
