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Measuring the Release of Lactate from Wild-Type and rd1 Mouse Retina
The retina has the highest energy consumption of any tissue in the human body. Remarkably, to satisfy its energy demand, the retina appears to rely...
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Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement
Enamel forming ameloblasts move away from the dentino-enamel junction and also move relative to each other to establish enamel shape during the...
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Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models
Alzheimer’s disease (AD) is characterized by genetic and multifactorial risk factors. Many studies correlate AD to sleep disorders. In this study, we...
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Derivation of embryonic stem cells from wild-derived mouse strains by nuclear transfer using peripheral blood cells
Wild-derived mouse strains have been extensively used in biomedical research because of the high level of inter-strain polymorphisms and phenotypic...
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Taxonomic assessment of two wild house mouse subspecies using whole-genome sequencing
The house mouse species complex ( Mus musculus ) is comprised of three primary subspecies. A large number of secondary subspecies have also been...
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No difference in cerebral perfusion between the wild-type and the 5XFAD mouse model of Alzheimer’s disease
Neuroimaging with [2,2-dimethyl-3-[(2 R ,3 E )-3-oxidoiminobutan-2-yl]azanidylpropyl]-[(2 R ,3 E )-3-hydroxyiminobutan-2-yl]azanide;oxo( 99 Tc)technetium-99(3+)...
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Assessing microbiome population dynamics using wild-type isogenic standardized hybrid (WISH)-tags
Microbiomes feature recurrent compositional structures under given environmental conditions. However, these patterns may conceal diverse underlying...
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The Tottering Mouse
In the late 1950s, a novel spontaneous mutation was found in the same litter of mice while breeding by Green and Sidman at the Roscoe B. Jackson...
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Infection of wild-caught wood mice (Apodemus sylvaticus) and yellow-necked mice (A. flavicollis) with tick-borne encephalitis virus
The distribution of tick-borne encephalitis virus (TBEV) is expanding to Western European countries, including the Netherlands, but the contribution...
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Immunopathological Disorders in Sheep, Goat, Wild Animals, and Laboratory Animals
Immune system protects the body from various infectious agents, toxic and allergic substances. It contains two interrelated responses i.e., innate...
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The gut microbiome changes in wild type and IL-18 knockout mice after 9.0 Gy total body irradiation
BackgroundRecent studies have shown that gut microbiome plays important roles in response to radiation exposure. IL-18, an inflammatory cytokine, is...
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Mouse Models of Phaeohyphomycosis
Infections by dematiaceous fungi especially phaeohyphomycosis are an emerging group of infectious diseases worldwide with a variety of clinical...
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The Rolling Nagoya Mouse
The natural mutant mouse rolling Nagoya is severely ataxic and frequently shows body roll-overs. The phenotype is inherited in an autosomal recessive...
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Molecular characterization of wild-type and HSAN2B-linked FAM134B
BackgroundFamily with sequence similarity 134, member B (FAM134B), also known as Reticulophagy regulator 1 (RETREG1), is an ER-phagy receptor...
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Lurcher Mouse
Lurcher mutant mouse is a natural model of hereditary cerebellar degeneration which is caused by a mutation in the δ2 glutamate receptor encoding...
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Therapeutic Strategies in BRAF V600 Wild-Type Cutaneous Melanoma
There have been many recent advances in melanoma therapy. While 50% of melanomas have a BRAF mutation and are a target for BRAF inhibitors, the...
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A New Mouse Strain with a Mutation in the NFE2L2 (NRF2) Gene
AbstractTranscription factor NRF2 is involved in inflammatory reactions, maintenance of redox balance, metabolism of xenobiotics, and is of...
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Regulation of Heart Contractility by M2 and M3 Muscarinic Receptors: Functional Studies Using Muscarinic Receptor Knockout Mouse
To investigate the functional roles of M2 and M3 muscarinic receptors in mouse atria, wild-type mice, muscarinic M2 or M3 single receptor knockout...
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Wild-type IDH2 is a therapeutic target for triple-negative breast cancer
Mutations in isocitrate dehydrogenases (IDH) are oncogenic events due to the generation of oncogenic metabolite 2-hydroxyglutarate. However, the role...
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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
RAS oncogenes (collectively NRAS , HRAS and especially KRAS ) are among the most frequently mutated genes in cancer, with common driver mutations...
