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Treatment outcome of IDH1/2 wildtype CNS WHO grade 4 glioma histologically diagnosed as WHO grade II or III astrocytomas
BackgroundIsocitrate dehydrogenase ( IDH)1/2 wildtype (wt) astrocytomas formerly classified as WHO grade II or III have significantly shorter PFS and...
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Astrocytoma (WHO Grade II)
A 28-year-old female, who had previous stereotactic biopsy for cerebral glioma 1 month ago, presented with generalized tonic-clonic seizures. She was...
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Astrocytoma (WHO Grade III)
A 36-year-old female presented with generalized tonic-clonic seizures. She had prior stereotactic biopsy and received conventional radiation therapy...
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Pilocytic Astrocytoma (WHO Grade I)
A 9-year-old boy, who had prior surgery for pilocytic astrocytoma 3 months ago, presented asymptomatic. He was treated with adjunctive; Linac-based...
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Anaplastic Ependymoma (WHO Grade III)
An 18-year-old male presented with medication-controlled generalized tonic-clonic seizures, and mild right-sided body weakness, following previous...
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Diffusion histogram profiles predict molecular features of grade 4 in histologically lower-grade adult diffuse gliomas following WHO classification 2021
ObjectivesIn the latest World Health Organization classification 2021, grade 4 adult diffuse gliomas can be diagnosed with several molecular features...
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Prognosis Individualized: Survival predictions for WHO grade II and III gliomas with a machine learning-based web application
WHO grade II and III gliomas demonstrate diverse biological behaviors resulting in variable survival outcomes. In the context of glioma prognosis,...
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Tumour growth rate predicts overall survival in patients with recurrent WHO grade 4 glioma
PurposeAccurate prognostication may aid in the selection of patients who will benefit from surgery at recurrent WHO grade 4 glioma. This study aimed...
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Perifocal edema is a risk factor for preoperative seizures in patients with meningioma WHO grade 2 and 3
BackgroundPatients with intracranial meningiomas frequently suffer from tumor-related seizures prior to resection, impacting patients’ quality of...
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Long-term outcomes of CNS WHO grade 2 oligodendroglioma in adult patients: a single-institution experience
PurposeOligodendrogliomas (ODGs) are a subtype of diffuse lower-grade gliomas with overall survival of > 10 years. This study aims to analyze...
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Survival pattern of metastatic renal cell carcinoma patients according to WHO/ISUP grade: a long-term multi-institutional study
The World Health Organization/International Society of Urological Pathology (WHO/ISUP) grading of renal cell carcinoma (RCC) is classified from grade...
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Associations between contrast-enhanced ultrasound features and WHO/ISUP grade of clear cell renal cell carcinoma: a retrospective study
BackgroundClear cell renal cell carcinoma (CCRCC) comprises 70%–80% of RCCs. The World Health Organization/International Society of Urology Pathology...
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IDH1R132H mutation increases radiotherapy efficacy and a 4-gene radiotherapy-related signature of WHO grade 4 gliomas
The prognosis for the WHO grade 4 IDH-mutant astrocytoma is better than IDH-wildtype glioblastoma (GBM) patients. The purpose of this study is to...
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Analysis of safety and efficacy of proton radiotherapy for IDH-mutated glioma WHO grade 2 and 3
PurposeProton beam radiotherapy (PRT) has been demonstrated to improve neurocognitive sequelae particularly. Nevertheless, following PRT, increased...
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Long-term follow up of patients with WHO grade 2 oligodendroglioma
PurposeSince the introduction of the molecular definition of oligodendrogliomas based on isocitrate dehydrogenase ( IDH )-status and the...
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Loss of H3K27me3 in WHO grade 3 meningioma
Immunohistochemical quantification of H3K27me3 was reported to distinguish meningioma patients with an unfavorable prognosis but is not yet...
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Is location more determining than WHO grade for long-term clinical outcome in patients with meningioma in the first two decades of life?
ObjectiveTo identify factors for tumor relapse and poor outcome in patients with meningiomas in the first two decades of life.
MethodsAll patients...
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A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4
Malignant brain tumors, known as H3K27-altered diffuse midline glioma (DMG) and H3G34-mutant diffuse hemispheric glioma (DHG), can affect individuals...
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Particle beam radiotherapy in the treatment of WHO grade 2 and 3 meningiomas: an early experience from Shanghai Proton and Heavy Ion Center
PurposeTo investigate the efficacy and safety of particle beam radiotherapy (PBRT) in the management of patients with WHO grade 2 and 3 meningiomas.
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Radiomics predict the WHO/ISUP nuclear grade and survival in clear cell renal cell carcinoma
ObjectivesThis study aimed to assess the predictive value of radiomics derived from intratumoral and peritumoral regions and to develop a radiomics...
