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Systemic Absorption Resulting from Tobramycin-Loaded Antibiotic Cement Spacers Used in the Treatment of Prosthetic Joint Infection
PurposeAntimicrobial cement spacer (ACS) placement has been a cornerstone of two-stage management of prosthetic hip and knee infection....
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Efficacy of adjunctive inhaled colistin and tobramycin for ventilator-associated pneumonia: systematic review and meta-analysis
IntroductionVentilator-associated pneumonia (VAP) presents a significant challenge in intensive care units (ICUs). Nebulized antibiotics,...
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Cuminaldehyde and Tobramycin Forestall the Biofilm Threats of Staphylococcus aureus: A Combinatorial Strategy to Evade the Biofilm Challenges
Staphylococcus aureus , an opportunistic Gram-positive pathogen, is known for causing various infections in humans, primarily by forming biofilms. The...
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Impact of pH modification of the empirically used tobramycin ophthalmic solution on MIC90 concentration in tears and aqueous humor of donkeys (Equus asinus)
BackgroundCommercial tobramycin ophthalmic solution is frequently used empirically to treat ocular disorders in equines, despite being primarily...
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Hydrophilic gold nanospheres: influence of alendronate, memantine, and tobramycin on morphostructural features
Turkevich gold nanospheres are the original nanospheres that have been modified over time. Its combination with targeting medications such as...
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Improved Aerosolization Stability of Inhalable Tobramycin Powder Formulation by Co-Spray Drying with Colistin
PurposeTobramycin shows synergistic antibacterial activity with colistin and can reduce the toxic effects of colistin. The purpose of this study is...
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Synergistic interaction of cuminaldehyde and tobramycin: a potential strategy for the efficient management of biofilm caused by Pseudomonas aeruginosa
Pseudomonas aeruginosa , an opportunistic pathogen, has been found to cause several chronic and acute infections in human. Moreover, it often shows...
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Neutralization of ionic interactions by dextran-based single-chain nanoparticles improves tobramycin diffusion into a mature biofilm
The extracellular matrix protects biofilm cells by reducing diffusion of antimicrobials. Tobramycin is an antibiotic used extensively to treat P....