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1. Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies

   Immunosenescence increases the risk and severity of diseases in elderly individuals and leads to impaired vaccine-induced immunity. With aging of the...

   Yingying Hou, Min Chen, ... Rongsheng Tong in npj Vaccines

   Article Open access 10 April 2024
   

2. Advances in the pathogenesis and therapeutic strategies of angioimmunoblastic T-cell lymphoma

   Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphomas with its cell origin determined to be follicular...

   Qingyang Zhang, Le Yin, ... Hongling Peng in Clinical and Experimental Medicine

   Article 27 September 2023
   

3. Therapeutic advantage of teriparatide in very elderly patients with proximal femoral fractures: a functional and BMD analysis

   Background

   Teriparatide, a recombinant parathyroid hormone, is pivotal in osteoporosis treatment, particularly in post-surgical recovery for hip...

   Ooi Chin Sheng, Wen-Tien Wu, ... Kuang-Ting Yeh in BMC Musculoskeletal Disorders

   Article Open access 13 April 2024
   

4. Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

   Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells...

   Xue Yang, Ying Wang, ... Yufang Shi in Biology Direct

   Article Open access 18 July 2023
   

5. Non-Surgical Therapeutic Strategies for Non-Melanoma Skin Cancers

   Non-melanoma skin cancer (NMSC) is a globally prevalent skin disease, with basal cell carcinoma and squamous cell carcinoma accounting for 99% of...

   Qingyu Zeng, Chengqian Chen, ... **uli Wang in Current Treatment Options in Oncology

   Article 14 December 2023
   

6. Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer

   The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER), due to genetic determinants and extrinsic environmental...

   Siqi Yuan, Dan She, ... Ling Ma in Molecular Medicine

   Article Open access 20 March 2024
   

7. Unveiling the role of CaMKII in retinal degeneration: from biological mechanism to therapeutic strategies

   Ca ²⁺ /calmodulin-dependent protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)/threonine (Thr) protein kinases that...

   Yuxin Sun, Mengyu Hao, ... Ye Tao in Cell & Bioscience

   Article Open access 09 May 2024
   

8. Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

   Sarcopenia is a multifactorial condition characterized by loss of muscle mass. It poses significant health risks in older adults worldwide. Both...

   Youle Zheng, ** Feng, ... Xu Wang in Archives of Pharmacal Research

   Article 09 April 2024
   

9. Boswellic Acid Nanoparticles: Promising Strategies for Increasing Therapeutic Effects

   Boswellic acids, the main active compound found in the oleo-gum resin of Boswellia serrata Roxb., Burseraceae, have been used in traditional and...

   Kiana Nakhaei, Sara Bagheri-Hosseini, ... Motahareh Boozari in Revista Brasileira de Farmacognosia

   Article 12 May 2023
   

10. Therapeutic anticoagulation complications in the elderly: a case report

    Background

    The demographic transition leads to a continuously growing number of elderly patients who receive therapeutic anticoagulation by reason of...

    Marcel Niemann, Karl F. Braun, ... Frank Graef in BMC Geriatrics

    Article Open access 05 February 2022
    

11. Bone cement reinforcement improves the therapeutic effects of screws in elderly patients with pelvic fragility factures

    Background

    Pelvic fragility fractures in elderly individuals present significant challenges in orthopedic and geriatric medicine due to reduced bone...

    Lecai Gao, Baorui **ng in Journal of Orthopaedic Surgery and Research

    Article Open access 18 March 2024
    

12. Arrhythmia Management in the Elderly

    The incidence of arrhythmias increases as patients age, likely reflecting both the aging conduction system and the increasing prevalence of...

    Ryan Wallace, Hugh Calkins in Cardiovascular Disease in the Elderly

    Chapter 2023
    

13. Current and emerging therapeutic strategies in adult T-cell leukemia–lymphoma

    Adult T-cell leukemia–lymphoma (ATL) is classified into four clinical subtypes: acute, lymphoma, chronic, and smoldering. Chronic ATL is further...

    Hiroo Katsuya in International Journal of Hematology

    Article 02 March 2023
    

14. Leveraging the glymphatic and meningeal lymphatic systems as therapeutic strategies in Alzheimer’s disease: an updated overview of nonpharmacological therapies

    Understanding and treating Alzheimer’s disease (AD) has been a remarkable challenge for both scientists and physicians. Although the amyloid-beta and...

    Douglas A. Formolo, Jiasui Yu, ... Suk-Yu Yau in Molecular Neurodegeneration

    Article Open access 20 April 2023
    

15. Prognostic value of pre-therapeutic nutritional risk factors in elderly patients with locally advanced esophageal squamous cell carcinoma receiving definitive chemoradiotherapy or radiotherapy

    Background

    The nutritional status of cancer patients is a crucial factor in determining their prognosis. The objective of this study was to...

    Jianjian Qiu, Jun Yang, ... Qiwei Yao in BMC Cancer

    Article Open access 28 June 2023
    

16. Impact of cancer diagnosis and treatment: a qualitative analysis of strains, resources and co** strategies among elderly patients in a rural setting in Ghana

    Background

    Rurality is fraught with numerous difficulties including a lack of advanced health facilities to provide health services, and an absence of...

    Adwoa Bemah Boamah Mensah, Maurice Mikare, ... Joe-Nat Clegg Lamptey in BMC Geriatrics

    Article Open access 05 September 2023

17. Inflammation in heart failure: pathophysiology and therapeutic strategies

    A role for inflammation in the development and progression of heart failure (HF) has been proposed for decades. Multiple studies have demonstrated...

    Jacinthe Boulet, Vikas S. Sridhar, ... Michel White in Inflammation Research

    Article Open access 28 March 2024
    

18. Thoracic Trauma in the Elderly

    In the setting of trauma, age-related changes to the respiratory system predispose the elderly patient to more severe traumatic injury and,...

    William Kelly, Irene Yu, ... T. Robert Qaqish in Acute Care Surgery in Geriatric Patients

    Chapter 2023
    

19. siRNA-Based Novel Therapeutic Strategies to Improve Effectiveness of Antivirals: An Insight

    Since the ground-breaking discovery of RNA interference (RNAi), scientists have made significant progress in the field of small interfering RNA...

    Krittika Chatterjee, Sagheerah Lakdawala, ... Deepak Choudhary in AAPS PharmSciTech

    Article 11 August 2023
    

20. Improving survival in metastatic renal cell carcinoma (mRCC) patients: do elderly patients benefit from expanded targeted therapeutic options?

    Introduction

    Treatment advances in metastatic renal cell carcinoma (mRCC) have improved overall survival (OS) in mRCC patients over the last two...

    Hendrik Eggers, Christoph Schünemann, ... Philipp Ivanyi in World Journal of Urology

    Article Open access 02 August 2022