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Structural mechanisms of TRPM7 activation and inhibition
The transient receptor potential channel TRPM7 is a master regulator of the organismal balance of divalent cations that plays an essential role in...
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TRPM7 kinase mediates hypomagnesemia-induced seizure-related death
Hypomagnesemia (HypoMg) can cause seizures and death, but the mechanism is unknown. Transient receptor potential cation channel subfamily M 7 (TRPM7)...
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TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness
IntroductionWe previously reported that TRPM7 regulates glioma cells’ stemness through STAT3. In addition, we demonstrated that FOSL1 is a response...
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TRPM7 mediates endoplasmic reticulum stress and ferroptosis in sepsis-induced myocardial injury
Transient receptor potential melastatin 7 (TRPM7), a non-selective cation channel, was significantly upregulated in the blood of patients with...
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The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis
Cancer or endothelial cells preferably catabolize glucose through aerobic glycolysis rather than oxidative phosphorylation. Intracellular ionic...
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TRPM7 Mediates Neuropathic Pain by Activating mTOR Signaling in Astrocytes after Spinal Cord Injury in Rats
In this study, we investigated whether transient receptor melastatin 7 (TRPM7), known as a non-selective cation channel, inhibits neuropathic pain...
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Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
BackgroundSepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by...
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Hypoxia-Induced Neurite Outgrowth Involves Regulation Through TRPM7
Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed divalent cation channel that plays a key role in cell functions such as...
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High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7
Abnormal visual experience during the critical period can cause deficits in visual function, such as amblyopia. High magnesium (Mg 2+ ) supplementary...
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TRPM7 Mediates BSCB Disruption After Spinal Cord Injury by Regulating the mTOR/JMJD3 Axis in Rats
After spinal cord injury (SCI), secondary injuries including blood cells infiltration followed by the production of inflammatory mediators are led by...
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Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice
Chronic inflammation of white adipose tissue is a key link between obesity and the associated metabolic syndrome. Transient receptor potential...
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LncRNA SNHG8 regulates the migration and angiogenesis of pHUVECs induced by high glucose via the TRPM7/ERK1/2 signaling axis
This study aimed to evaluate the regulatory effect and molecular mechanism of long noncoding RNA small nucleolus RNA host gene 8 (LncRNA SNHG8) in...
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TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt
Hyperaldosteronism causes cardiovascular disease as well as hypomagnesemia. Mechanisms are ill-defined but dysregulation of TRPM7, a Mg 2+ -permeable...
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Knockdown of circ-Gatad1 alleviates LPS induced HK2 cell injury via targeting miR-22-3p/TRPM7 axis in septic acute kidney
BackgroundSepsis is a life-threatening, systemic inflammatory disease that can lead to a variety of conditions, including septic acute kidney injury...
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Involvement of TRPM7 Channel on the Induction of Diabetic Neuropathic Pain in Mice: Protective Role of Selenium and Curcumin
Excessive levels of the mitochondrial reactive oxygen radical (mitSOX) and Ca 2+ influx were found to cause neuropathic pain in patients with diabetes...
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Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity
Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is fundamental to developmental biology, organ physiology, and...
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Structural mechanism of TRPM7 channel regulation by intracellular magnesium
Zn 2+ , Mg 2+ and Ca 2+ are essential divalent cations implicated in many metabolic processes and signalling pathways. An emerging new paradigm is that...
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TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts
Sustained exposure of the lung to various environmental or occupational toxins may eventually lead to pulmonary fibrosis, a devastating disease with...
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Low-intensity pulsed ultrasound/nanomechanical force generators enhance osteogenesis of BMSCs through microfilaments and TRPM7
BackgroundLow-intensity pulsed ultrasound (LIPUS) has been reported to accelerate fracture healing, but the mechanism is unclear and its efficacy...
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SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
PurposeChronic hepatitis B virus (HBV) infection is the primary risk factor for the malignant progression of hepatocellular carcinoma (HCC). It has...
