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Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants
Epilepsy is a common neurological disorder characterized by abnormal activity of neuronal networks, leading to seizures. The racetam class of...
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Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density
ObjectiveDespite being one of the most prevalent neurological diseases, the pathophysiology of essential tremor (ET) is not fully understood....
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Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined...
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Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane
Synaptic vesicles are small membrane-enclosed organelles that store neurotransmitters at presynaptic terminals. The uniform morphology of synaptic...
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Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic...
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Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum
BackgroundSynapse loss is an early event that precedes neuronal death and symptom onset and is considered the best neuropathological correlate of...
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PET Imaging of Synaptic Vesicle Protein 2A
The synaptic vesicle protein 2A (SV2A) is an integral 12-transmembrane domain glycoprotein located in the membrane of synaptic vesicles and widely...
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Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
BackgroundThe endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic terminal, to move...
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Synaptic Vesicle Pool Monitoring with Synapto-pHluorin
Synaptic vesicle exocytosis can be monitored with genetically encoded pH sensors in an in vitro fluorescence microscopy setup. Here, we describe a...
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Synapsin condensation controls synaptic vesicle sequestering and dynamics
Neuronal transmission relies on the regulated secretion of neurotransmitters, which are packed in synaptic vesicles (SVs). Hundreds of SVs accumulate...
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Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior
BackgroundThe VPS50 protein functions in synaptic and dense core vesicle acidification, and perturbations of VPS50 function produce behavioral...
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Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles
Neurotransmitter release relies on the regulated fusion of synaptic vesicles (SVs) that are tightly packed within the presynaptic bouton of neurons....
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APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
Trisomy 21 (T21) causes Down syndrome and an early-onset form of Alzheimer’s disease (AD). Here, we used human induced pluripotent stem cells...
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Exposure to an enriched environment modulates the synaptic vesicle cycle in a mouse spinal cord injury model
Spinal cord injury (SCI) leads to motor and sensory impairment below the site of injury, thereby necessitating rehabilitation. An enriched...
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Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer’s disease
BackgroundPrevious studies have demonstrated that early intervention was the best plan to inhibit the progression of Alzheimer’s disease (AD), which...
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Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis
Compensatory endocytosis keeps the membrane surface area of secretory cells constant following exocytosis. At chemical synapses, clathrin-independent...
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Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)
Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A, SV2B, and SV2C. This protein family has attracted attention in...
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Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations
We study the formation of vesicle condensates induced by the protein synapsin, as a cell-free model system mimicking vesicle pool formation in the...
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A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [18F]SDM-16
PurposeTo quantify the synaptic vesicle glycoprotein 2A (SV2A) changes in the whole central nervous system (CNS) under pathophysiological conditions,...
