Search
Search Results
-
Synaptic Tagging and Capture From Synapses to Behavior
This reference presents a detailed exploration of the synaptic tagging and capture model, which has been proposed to provide a conceptual basis for...
-
Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease
The associations of synaptic loss with amyloid-β (Aβ) and tau pathology measured by positron emission tomography (PET) and plasma analysis in...
-
The intersection of sleep and synaptic translation in synaptic plasticity deficits in neurodevelopmental disorders
Individuals with neurodevelopmental disorders experience persistent sleep deficits, and there is increasing evidence that sleep dysregulation is an...
-
Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles
Neuronal communication relies on the release of neurotransmitters from various populations of synaptic vesicles. Despite displaying vastly different...
-
Synaptic and mitochondrial mechanisms behind alcohol-induced imbalance of excitatory/inhibitory synaptic activity and associated cognitive and behavioral abnormalities
Alcohol consumption during pregnancy can significantly impact the brain development of the fetus, leading to long-term cognitive and behavioral...
-
Synaptic Integration at Neuron-OPC Synapses
The synapses between neurons and oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS) have similar ultrastructures as...
-
Synaptic Scaling and Homeostasis
Synaptic scaling is a hypothesis that is accepted by many neuroscientists. Its main premise is that both excitatory and inhibitory synaptic weights...
-
Synaptic Vesicles Methods and Protocols
This book provides protocols on the preparation of synaptic vesicles from different model systems and provides instructions for functional...
-
Compartmentalization of Synaptic Tagging and Capture
Testing of the synaptic tagging and capture (STC) hypothesis has produced remarkable work on the understanding of how a single neuron undergoes...
-
Synaptic variation reduction via embedding Au nanocrystals in resistive switching layer and bottom electrode interface for CuTe/CuO/TiN-stacked synaptic device
Reliable artificial synaptic devices are essential for the stable and fast training of artificial neural networks (ANNs). Specifically, synaptic...
-
Molecular Mechanisms Underlying Synaptic Tagging and Consolidation
After a synapse undergoes long-term potentiation (LTP), it acquires a newly remodeled molecular and structural organization. This reorganization over...
-
Activity-Dependent Protein Transport as a Synaptic Tag
The “synaptic tagging and capture” hypothesis proposes that a hypothetical, cell biological mark is activated in the synapses undergoing early-phase...
-
Synaptic PET Imaging in Neurodegeneration
Synaptic vesicle glycoprotein 2A (SV2A) is an integral glycoprotein in synaptic vesicle membranes and has been investigated as a potential positron...
-
Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density
ObjectiveDespite being one of the most prevalent neurological diseases, the pathophysiology of essential tremor (ET) is not fully understood....
-
New Aspects in Analyzing the Synaptic Organization of the Brain
This volume looks at the latest methodological developments used in the field to investigate the synaptic organization of the brain from different...
-
Understanding neural circuit function through synaptic engineering
Synapses are a key component of neural circuits, facilitating rapid and specific signalling between neurons. Synaptic engineering — the synthetic...
-
Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles
Acutely silencing specific neurons informs about their functional roles in circuits and behavior. Existing optogenetic silencers include ion pumps,...
-
Modulation of synaptic transmission through O-GlcNAcylation
O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by...
-
Oxysterols in Central and Peripheral Synaptic Communication
Cholesterol is a key molecule for synaptic transmission, and both central and peripheral synapses are cholesterol rich. During intense neuronal...
-
Synaptic Effects Induced by Alcohol
Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in synaptic function are prominent among these effects. Acute...