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Secretory expression of recombinant small laccase genes in Gram-positive bacteria
BackgroundLaccases are multicopper enzymes that oxidize a wide range of aromatic and non-aromatic compounds in the presence of oxygen. The majority...
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Diagnostic Utility of Expression Pattern of S100/Mammaglobin/SOX10/DOG 1 Immunohistochemistry in Differentiation of Secretory and Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis
Secretory carcinoma (SC) is a relatively new disease entity, separate from acinic cell carcinoma (AciCC), which frequently displays ETV6-NTRK3 gene...
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Full-length versus truncated α-factor secretory signal sequences for expression of recombinant human insulin precursor in yeast Pichia pastoris: a comparison
BackgroundHuman insulin was the first FDA-approved biopharmaceutical drug produced through recombinant DNA technology. The previous studies...
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Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features
BackgroundCellular senescence is a state characterized by cell-cycle arrest and apoptotic resistance. Senescence in cancer may be induced by...
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Small-Scale Secretory VHH Expression in Saccharomyces cerevisiae
After isolation of a single-domain antibody (VHH) binding to an antigen of interest, the soluble VHH is often produced in Escherichia coli. However,...
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Combining manipulation of integration loci and secretory pathway on expression of an Aspergillus niger glucose oxidase gene in Trichoderma reesei
Trichoderma reesei ( T. reesei ) is well-known for its excellent ability to secret a large quantity of cellulase. However, unlike the endogenous...
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Collaborative Expression: Transcriptomics of Conus virgo Suggests Contribution of Multiple Secretory Glands to Venom Production
Venomous marine gastropods of the family Conidae are among the most diversified predators in marine realm—in large due to their complex venoms....
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Secretory expression of β-1,3-glucomannanase in the oleaginous yeast Rhodosporidium toruloides for improved lipid extraction
Lipids produced by oleaginous yeasts are considered as sustainable sources for the production of biofuels and oleochemicals. The red yeast Rhodosporidi...
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Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins
Tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) are essential for pigmentation. They are generally classified as type-3...
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SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms...
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Analysis of Golgi Secretory Functions in Cancer
Cancer cells utilize secretory pathways for paracrine signaling and extracellular matrix remodeling to facilitate directional cell migration,...
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NKX3.1 Expression and Molecular Characterization of Secretory Myoepithelial Carcinoma (SMCA): Advancing the Case for a Salivary Mucous Acinar Phenotype
BackgroundSecretory myoepithelial carcinomas (SMCA) are rare, mucinous, signet ring predominant tumors with primitive myoepithelial features. While...
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Expression of secretory calcium-binding phosphoprotein (scpp) genes in medaka during the formation and replacement of pharyngeal teeth
BackgroundAnalyses of tooth families and tooth-forming units in medaka with regard to tooth replacement cycles and the localization of odontogenic...
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Nutrient deprivation alters the rate of COPII subunit recruitment at ER subdomains to tune secretory protein transport
Co-assembly of the multilayered coat protein complex II (COPII) with the Sar1 GTPase at subdomains of the endoplasmic reticulum (ER) enables...
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Exploring the co-operativity of secretory structures for defense and pollination in flowering plants
Main conclusionIn flowers multiple secretory systems cooperate to deliver specialized metabolites to support specific roles in defence and...
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The insulin secretory granule is a hotspot for autoantigen formation in type 1 diabetes
In type 1 diabetes, the insulin-producing beta cells of the pancreas are destroyed through the activity of autoreactive T cells. In addition to...
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Secretory carcinoma of the salivary gland is rich in lactoferrin: a possible lactational-like differentiation?
PurposeIt has been hypothesised that secretory carcinoma of the salivary gland (SCsg) might have a lactational-like differentiation. Therefore, we...
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Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging
Aging negatively affects the appearance and texture of the skin owing to the accumulation of senescent fibroblasts within the dermis. Senescent cells...
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Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches
Cancer cells inevitably interact with neighboring host tissue-resident cells during the process of metastatic colonization, establishing a metastatic...
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The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21,...
