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Secretory carcinoma of the salivary gland is rich in lactoferrin: a possible lactational-like differentiation?

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Abstract

Purpose

It has been hypothesised that secretory carcinoma of the salivary gland (SCsg) might have a lactational-like differentiation. Therefore, we aimed to assess the immunoexpression of breast hormonal receptors and milk-related proteins in cases of SCsg and other salivary gland tumours with prominent secretory activity.

Methods

Immunohistochemistry against prolactin and growth hormone receptors, lactoferrin, human milk fat globule 1, MUC 1 and MUC4 was performed in twelve cases of SCsg and 47 other salivary gland tumours.

Results

Most cases of SCsg were negative for prolactin and growth hormone receptors. All cases of SCsg showed enhanced membranous-cytoplasmic staining for human milk fat globule 1, a pattern seen in other tumour groups. Only SCsg showed widespread strong staining for lactoferrin, concomitantly in the cell compartment and secretion. The other positive tumour types exhibited restricted staining. MUC1 and MUC4 showed no distinct pattern of expression.

Conclusion

Although SCsg failed to demonstrate a complete lactational-like differentiation, lactoferrin showed a distinctive expression pattern in SCsg compared to other tumour types, which makes it a good marker to help in its differential diagnosis.

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Funding

This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo [grant #17/04546–9].

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Authors and Affiliations

  1. School of Dentistry, Universidade de São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil

    Marcos Custódio, Fabio Daumas Nunes, Maria Fernanda Setúbal Destro Rodrigues, Suzana C. O. M. de Sousa & Bruno Tavares Sedassari

  2. School of Medicine, Universidade Federal Do Maranhão, Imperatriz, MA, Brazil

    Marcos Custódio

  3. School of Medicine, Universidade Estadual de Campinas, Campinas, SP, Brazil

    Albina Altemani

  4. School of Dentistry, São Leopoldo Mandic, Campinas, SP, Brazil

    Fabricio Passador-Santos

  5. Universidade Nove de Julho, São Paulo, SP, Brazil

    Maria Fernanda Setúbal Destro Rodrigues & Bruno Tavares Sedassari

Authors
  1. Marcos Custódio
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  2. Fabio Daumas Nunes
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  3. Albina Altemani
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  4. Fabricio Passador-Santos
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  5. Maria Fernanda Setúbal Destro Rodrigues
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  6. Suzana C. O. M. de Sousa
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  7. Bruno Tavares Sedassari
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Corresponding author

Correspondence to Marcos Custódio.

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All authors certify that they have no affiliations with or involvement in any organisation or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of University of São Paulo (protocol n. #1.860.949).

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Custódio, M., Nunes, F.D., Altemani, A. et al. Secretory carcinoma of the salivary gland is rich in lactoferrin: a possible lactational-like differentiation?. Eur Arch Otorhinolaryngol 280, 3891–3896 (2023). https://doi.org/10.1007/s00405-023-08023-8

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  • DOI: https://doi.org/10.1007/s00405-023-08023-8

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