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Pyroptosis Methods and Protocols
This volume explores techniques used to study and understand the latest research on pyroptosis. The chapters in this book cover topics such as...
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Molecular Mechanisms of Pyroptosis
Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in many different diseases. Pyroptosis was initially defined...
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Assessing Cytoskeletal Destruction During Pyroptosis
Pyroptosis is an inflammatory form of cell death driven by the activation of caspase-1 and/or caspase-11 which cleaves and activates the pore-forming...
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New prospects of cancer therapy based on pyroptosis and pyroptosis inducers
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules....
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Pyroptosis Signature Gene CHMP4B Regulates Microglia Pyroptosis by Inhibiting GSDMD in Alzheimer’s Disease
In this study, we aimed to work through the key genes involved in the process of pyroptosis in Alzheimer’s disease (AD) to identify potential...
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Inducing Pyroptosis Via the Pyrin Inflammasome
The pyrin inflammasome detects bacterial toxins and effectors that inhibit RhoA GTPases and triggers inflammatory cytokine release and a fast cell...
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Assessment of HMGB1 Release During Experimentally Induced Pyroptosis
Inflammasomes are multiprotein complexes that can be activated by a wide array of infectious and inflammatory agents. Inflammasome activation...
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Live Imaging of Pyroptosis in Primary Murine Macrophages
Inflammasomes are the ultimate weapon of the macrophage immune arsenal. Inflammasome signalling in macrophages triggers pyroptosis, a lytic cell...
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Pyroptosis in microbial infectious diseases
Pyroptosis is a gasdermins-mediated programmed cell death that plays an essential role in immune regulation, and its role in autoimmune disease and...
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Inducing Pyroptosis with FlaTox, RodTox, or NeedleTox
Targeted activation of the NAIP-NLRC4 inflammasome has proven very useful in the study of pyroptosis. FlaTox and derivative LFn-NAIP-ligand cytosolic...
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Pyroptosis Induction and Visualization at the Single-Cell Level Using Optogenetics
Pyroptosis has been identified as a pro-inflammatory form of programmed cell death. It can be triggered by different stimuli including pathogen...
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Ferroptosis and Pyroptosis in Epilepsy
Epilepsy is sudden, recurrent, and transient central nervous system dysfunction caused by abnormal discharge of neurons in the brain. Ferroptosis and...
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Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation
BackgroundThe prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although...
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Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis
Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However,...
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The role of pyroptosis in viral infection
Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death, which is an important natural immune response. Pyroptosis plays...
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Molecular mechanism of bovine Gasdermin D-mediated pyroptosis
Pyroptosis is a form of programmed cell death characterized by cell swelling, pore formation in the plasma membrane, lysis, and releases of...
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The roles of pyroptosis in genitourinary diseases
Pyroptosis, a form of programmed cell death distinct from apoptosis and necrosis, is thought to be closely associated with the pathogenesis of...
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Pyroptosis Inhibition in Disease Treatment: Opportunities and Challenges
Programmed cell death (PCD) is at the center of immune responses, with different types of PCD occurring based on bodily conditions at a given moment....
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Research Progress on Pyroptosis in Hematological Malignancies
Pyroptosis is a kind of programmed cell death dependent on the caspase pathway that is different from apoptosis and necrosis. Recent studies have...
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Synergistically Augmenting Cancer Immunotherapy by Physical Manipulation of Pyroptosis Induction
Pyroptosis is a newly recognized type of programmed cell death mediated by the gasdermin family and caspase. It is characterized by the formation of...
