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First Proteome Analysis of Poplar-Type Propolis
Propolis is a natural mixture of honeybee-released and plant-derived compounds produced by honeybees. Poplar propolis is rich in bioactive...
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In situ analysis of osmolyte mechanisms of proteome thermal stabilization
Organisms use organic molecules called osmolytes to adapt to environmental conditions. In vitro studies indicate that osmolytes thermally stabilize...
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Quantitative proteome-wide O-glycoproteomics analysis with FragPipe
Identification of O-glycopeptides from tandem mass spectrometry data is complicated by the near complete dissociation of O-glycans from the peptide...
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An integrated workflow for quantitative analysis of the newly synthesized proteome
The analysis of proteins that are newly synthesized upon a cellular perturbation can provide detailed insight into the proteomic response that is...
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KOPI: Kinase inhibitOr Proteome Impact analysis
Kinase inhibitors often exert on/off-target effects, and efficient data analysis is essential for assessing these effects on the proteome. We...
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Cell membrane proteome analysis in HEK293T cells challenged with α-synuclein amyloids
Amyloids interact with plasma membranes. Extracellular amyloids cross the plasma membrane barrier. Internalized extracellular amyloids are reported...
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Simultaneous proteome localization and turnover analysis reveals spatiotemporal features of protein homeostasis disruptions
The spatial and temporal distributions of proteins are critical to protein function, but cannot be directly assessed by measuring protein bundance....
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An Optimized Data-Independent Acquisition Strategy for Comprehensive Analysis of Human Plasma Proteome
Cartography of the plasma proteome remains technically challenging, primarily due to the abundance and dynamic range of plasma proteins and their...
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Unraveling the surface marker signature of cell-derived vesicles via proteome analysis and nanoparticle flow cytometry
The cell-derived vesicles (CDVs) obtained using a proprietary extrusion process are the foundation of BioDrone platform technology. With superior...
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In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease
Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Monitoring the early diagnostic period and...
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Modulation of cellular transcriptome and proteome composition by azidohomoalanine—implications on click chemistry–based secretome analysis
AbstractThe analysis of the secretome provides important information on proteins defining intercellular communication and the recruitment and...
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Serum proteome analysis identifies a potential biomarker for axial psoriatic arthritis
BackgroundTo identify potential serum biomarkers for differentiating between axial psoriatic arthritis (axPsA) and peripheral psoriatic arthritis...
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Comparative proteome and serum analysis identified FSCN1 as a marker of abiraterone resistance in castration-resistant prostate cancer
BackgroundAbiraterone (Abi) is an androgen receptor signaling inhibitor that significantly improves patients’ life expectancy in metastatic prostate...
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Mitochondrial ATP generation is more proteome efficient than glycolysis
Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily...
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Proteome allocation is linked to transcriptional regulation through a modularized transcriptome
It has proved challenging to quantitatively relate the proteome to the transcriptome on a per-gene basis. Recent advances in data analytics have...
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On the Feasibility of Using an Ultra-Fast DirectMS1 Method of Proteome-Wide Analysis for Searching Drug Targets in Chemical Proteomics
AbstractProtein quantitation in tissue cells or physiological fluids based on liquid chromatography/mass spectrometry is one of the key sources of...
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Comparative proteome analysis identifies species-specific signature proteins in Aspergillus pathogens
AbstractAspergillus flavus and Aspergillus fumigatus are important human pathogens that can infect the lung and cornea. During infection, Aspergillus ...
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Mitochondrial proteome research: the road ahead
Mitochondria are multifaceted organelles with key roles in anabolic and catabolic metabolism, bioenergetics, cellular signalling and nutrient...
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Amyloid β accelerates age-related proteome-wide protein insolubility
Loss of proteostasis is a highly conserved feature of aging across model organisms and results in the accumulation of insoluble protein aggregates....
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Discovery of metal-binding proteins by thermal proteome profiling
Metal-binding proteins (MBPs) have various and important biological roles in all living species and many human diseases are intricately linked to...
