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C-terminal truncation of the hemagglutinin-neuraminidase (HN) protein enhances the virulence and immunogenicity of Newcastle disease virus (NDV) vaccine strain V4
The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is a multifunctional protein with receptor recognition ability that...
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Double truncation method for controlling local false discovery rate in case of spiky null
Many multiple test procedures, which control the false discovery rate, have been developed to identify some cases (e.g. genes) showing statistically...
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C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone
α-Synuclein (α-syn) is the main protein component of Lewy bodies, the major pathological hallmarks of Parkinson’s disease (PD). C-terminally...
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A unique self-truncation of bacterial GH5 endoglucanases leads to enhanced activity and thermostability
Backgroundβ-1,4-endoglucanase (EG) is one of the three types of cellulases used in cellulose saccharification during lignocellulosic...
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TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition
The histone acetyltransferase p300/CBP is composed of several conserved domains, among which, the TAZ2 domain is known as a protein-protein...
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Molecular mechanism of hyperactivation conferred by a truncation of TRPA1
A drastic TRPA1 mutant (R919*) identified in CRAMPT syndrome patients has not been mechanistically characterized. Here, we show that the R919* mutant...
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High-Throughput Protein Expression Screening of Cell-Surface Protein Ectodomains
Cell-surface receptors can be difficult to express and purify for structural and biochemical studies due to low expression levels, misfolding,...
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Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau
Alteration of the levels, localization or post-translational processing of the microtubule associated protein Tau is associated with many...
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Truncation mutations in MYRF underlie primary angle closure glaucoma
Mutations in myelin regulatory factor ( MYRF ), a gene mapped to 11q12-q13.3, are responsible for autosomal dominant high hyperopia and seem to be...
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Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
BackgroundInterferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells...
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Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids
N -methyl- d -aspartate receptors (NMDARs) play a critical role in normal brain function, and variants in genes encoding NMDAR subunits have been...
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Truncation of the calmodulin binding domain in rice glutamate decarboxylase 4 (OsGAD4) leads to accumulation of γ-aminobutyric acid and confers abiotic stress tolerance in rice seedlings
GABA (Gamma-aminobutyric acid) is a non-protein amino acid widely known as major inhibitory neurotransmitter. It is synthesized from glutamate via...
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Multiobjective Approach to Gene Ontology-Based Protein-Protein Interaction Prediction
Protein-protein interactions (PPI) involve the binding of proteins to perform various biological functions, and accurately predicting them is vital...
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N-terminal truncated phospholipase A1 accessory protein PlaS from Serratia marcescens alleviates inhibitory on host cell growth and enhances PlaA1 enzymatic activity
Phospholipase A1 (PLA1) is a kind of specific phospholipid hydrolase widely used in food, medical, textile. However, limitations in its expression...
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Truncation of the TPR domain of OGT alters substrate and glycosite selection
O-GlcNAc transferase (OGT) is an essential enzyme that installs O-linked N-acetylglucosamine (O-GlcNAc) to thousands of protein substrates. OGT and...
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Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
Post-translational modifications to the carboxyl (C) terminus domain of α-synuclein can play an important role in promoting the pathologic...
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Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload
Engineered cardiac microtissues were fabricated using pluripotent stem cells with a hypertrophic cardiomyopathy associated c. 2827 C>T; p.R943x...
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Structural and functional insights into the helicase protein E5 of Mpox virus
Mpox virus (MPXV) can cause mpox in humans. Due to its quick and wide spread in the past two years, mpox has turned into a significant public health...
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Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance
Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and silencing, gene-containing...
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In Vitro Determination of Protein Nutritional Indexes
Most of the recent studies investigating the effects of sourdough on baked goods have highlighted its role in improving different nutritional...