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Inducibility of Metabolizing Enzymes
An important toxicologically relevant feature associated with foreign compound metabolism is the inducibility of metabolizing enzymes. Some...
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Phase II Detoxification Enzymes
Phase I enzymes catalyze the activation metabolism of foreign compounds. Their functionalization reactions incorporate a functional group into a...
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Inducibility of Metabolizing Enzymes
Metabolic enzyme inducibility is of major significance, because it plays an important role in the susceptibility of individuals to foreign...
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Pharmacogenomics of Drug-Metabolizing Enzymes
The pharmacogeneticsPharmacogenetics of drug-metabolizing enzymesDrug-Metabolizing Enzymes studies the relationship between an individual's genetic...
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Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
Selective chemical inhibitors are critical for reaction phenoty** to identify drug-metabolizing enzymes that are involved in the elimination of...
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Phase I Activation Enzymes
A vast majority of chemical reactions in living cells exhibit kinetic barriers that prevent the reactions from occurring spontaneously. Kinetic...
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Genetic polymorphisms in phase II metabolizing enzymes in alcoholic and idiopathic chronic pancreatitis: Indian scenario
AimTo study polymorphisms in glutathione-S-transferases (GST-T1, GST-M1, GST-P1) and uridine-5′-diphosphate-glucuronosyl-transferases (UGT1A7) genes...
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Pharmacokinetic modulation of substrate drugs via the inhibition of drug-metabolizing enzymes and transporters using pharmaceutical excipients
BackgroundPharmaceutical excipients are used for formulating drugs to suit their intended use and effect. These excipients influence drug solubility,...
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Metabolic Enzymes: Polymorphisms and Species Differences
Before elimination from the body, foreign compounds to which humans are exposed undergo metabolic conversion mediated by phase I and phase II...
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Marine Enzymes
Marine enzyme biotechnology can offer novel biocatalysts with properties like high salt tolerance, hyperthermostability, barophilicity, cold...
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Pollutants enhance IgE sensitization in the gut via local alteration of vitamin D-metabolizing enzymes
Mechanisms linking ingested pollutants to increased incidence of allergy are poorly understood. We report that mice exposed to low doses of cadmium...
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Hepatic drug-metabolizing enzymes and drug transporters in Wilson’s disease patients with liver failure
BackgroundWilson’s disease is a genetic disorder inherited in a recessive manner, caused by mutations in the copper-transporter ATP7B. Although it is...
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Pharmacogenomics in Drug Metabolism Enzymes and Transporters
The safe and effective use of drug therapies play a critical role in treating disease. Interindividual variability in drug metabolism and transport...
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The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver
BackgroundOur recent studies showed that prolonged administration of novel atypical antipsychotics affected the expression and activity of cytochrome...
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Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier
BackgroundAppropriate interactions between antiretroviral therapies (ART) and drug transporters and metabolizing enzymes at the blood brain barrier...
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Role of Genetic Polymorphisms in Drug-Metabolizing Enzyme-Mediated Toxicity and Pharmacokinetic Resistance to Anti-Cancer Agents: A Review on the Pharmacogenomics Aspect
The inter-individual differences in cancer susceptibility are somehow correlated with the genetic differences that are caused by the polymorphisms....
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Characteristics of Major Drug Metabolizing Cytochrome P450 Enzymes
Cytochrome P450 (CYP) enzymes have been widely studied for drug discovery and development. While much has been discovered in terms of characteristics...
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The function of microbial enzymes in breaking down soil contaminated with pesticides: a review
The use of pesticides and the subsequent accumulation of residues in the soil has become a worldwide problem. Organochlorine (OC) pesticides have...
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Enzymes in the Chemical and Pharmaceutical Industry
Enzymes are used today in the chemical and pharmaceutical industry to produce a wide range of products. In this chapter, you will be introduced to...